Detailed information of TA system TA183744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 59363..60015
• Replicon: chromosome
• Accession: NZ_CP065990
• Organism: Veillonella parvula strain FDAARGOS_1046

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I6I03_RS00300
• Protein ID: WP_012864932.1
• Coordinates: 59363..59548 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D1BPU6
• Locus tag: I6I03_RS00305
• Protein ID: WP_012864931.1
• Coordinates: 59617..60015 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I03_RS00260	54631..55002	+	372	Protein_50	hypothetical protein	-
I6I03_RS00265	55032..55625	+	594	WP_012864940.1	hypothetical protein	-
I6I03_RS00270	55729..56235	+	507	WP_012864939.1	YfbM family protein	-
I6I03_RS00275	56249..56536	+	288	WP_012864938.1	DUF2695 domain-containing protein	-
I6I03_RS00280	56674..57240	-	567	WP_012864937.1	NAD(P)H-dependent oxidoreductase	-
I6I03_RS00285	57473..57970	+	498	WP_012864936.1	ECF transporter S component	-
I6I03_RS00290	58470..58847	-	378	WP_012864934.1	carboxymuconolactone decarboxylase family protein	-
I6I03_RS00295	58914..59273	+	360	WP_012864933.1	MerR family transcriptional regulator	-
I6I03_RS00300	59363..59548	+	186	WP_012864932.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6I03_RS00305	59617..60015	+	399	WP_012864931.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6I03_RS00310	60159..60503	+	345	WP_012864930.1	alkylphosphonate utilization protein	-
I6I03_RS00315	60605..60997	+	393	WP_012864929.1	hypothetical protein	-
I6I03_RS00320	61011..61523	+	513	WP_012864928.1	phosphatidylglycerophosphatase A	-
I6I03_RS00325	61587..62126	+	540	WP_012864927.1	cysteine hydrolase	-
I6I03_RS00330	62487..63116	+	630	WP_012864926.1	superoxide dismutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-111)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7038.46 Da
• Isoelectric Point: 10.8174

>T183744 WP_012864932.1 NZ_CP065990:59363-59548 [Veillonella parvula]
MTTPKELMKDLKKDGWYIDRIKGSHHILKHPIKAGRVTIPLHKEDLKPKTLQTILKQAGLK

Nucleotide

• Length: 186 bp

>T183744 NZ_CP087171:1768848-1769042 [Pseudomonas atacamensis]
ATGAAGGAGCTGGAGGAGGCGGGCTGGACGCTGGATCGGGTTGCGGGCAATCATCACATCTTCACTCATCGTTACTACCC
GAACACGATTGCCGTCCCGCATCCGAAAAAGGATTTACCGCTGGGGACAGTCAAAAGCATTCGGCGGCGCGCGGGGTTAT
TCAGCCCGCCAACCCGTCATGAAGGAGATCCGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 15072.06 Da
• Isoelectric Point: 4.2501

>AT183744 WP_012864931.1 NZ_CP065990:59617-60015 [Veillonella parvula]
MRKEMYPAIFSTDGKNGYTVSFPDLLGCVTEGDTLCEAVEMAEDALGIYLYSLSEDGEEFPEASNPIDIKCNKGEFIDLV
KWDEEEYLKRTDNKAVKKTLTIPSWLNHKAEEKQLNFSQILQRALKQELELV

Nucleotide

• Length: 399 bp

>AT183744 NZ_CP087171:1769042-1769446 [Pseudomonas atacamensis]
ATGCAATATCCCATCTGCATCGAGTGGGGTGACGAGAACACTGCCATCGGCATTCAGATCCCCGATATCCCCGGCGCAGT
CACGGTCGGGGACAGCTTTGAGGAGGCTTACAACGCGGCCGTGGAAGTGGCTCACCTCATGCTGCAGGAGATCGCGGCGG
CCGGTCAGGCGATTCCGATGCCGACCTCGGCAGCGGCGCATCGCAATCATCCGGATTTTGCCGAGATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTACCTGGGCAAGACCGAAAAGGTCAACGTTACGCTGCCCGGCTATGTCATTCAGCGTAT
TGATCGCTATGTACGCGAGCACAACGTCAAAAGCCGCTCCTCGTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGGT
ATTGA

Structures

Antitoxin

• AlphaFold DB: D1BPU6