Detailed information of TA system TA183743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3357223..3357743
• Replicon: chromosome
• Accession: NZ_CP065989
• Organism: Brevibacterium casei strain FDAARGOS_990

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: I6H47_RS14875
• Protein ID: WP_198499159.1
• Coordinates: 3357223..3357513 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: I6H47_RS14880
• Protein ID: WP_198499160.1
• Coordinates: 3357510..3357743 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H47_RS14870	3355386..3357182	+	1797	WP_198501000.1	BCCT family transporter	-
I6H47_RS14875	3357223..3357513	-	291	WP_198499159.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6H47_RS14880	3357510..3357743	-	234	WP_198499160.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
I6H47_RS14885	3357927..3358199	+	273	WP_198499161.1	hypothetical protein	-
I6H47_RS14890	3358212..3359132	-	921	WP_198499162.1	bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase	-
I6H47_RS14895	3359148..3359852	-	705	WP_198499163.1	ribonuclease III	-
I6H47_RS14900	3359856..3360059	-	204	WP_063249041.1	50S ribosomal protein L32	-
I6H47_RS14905	3360062..3360580	-	519	WP_198499164.1	DUF177 domain-containing protein	-
I6H47_RS14910	3360771..3361259	+	489	WP_198499165.1	hypothetical protein	-
I6H47_RS14915	3361278..3362465	-	1188	WP_198499166.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11380.77 Da
• Isoelectric Point: 10.4791

>T183743 WP_198499159.1 NZ_CP065989:c3357513-3357223 [Brevibacterium casei]
VNRYRLSAAAQRDLSEIWDYTERRWDSNQAENYMQQIRSAVEHIAADPGRGRAVNEIREGYRRFATGSHVLFYRVRPKGV
DVIRVLHQRMDPTRHL

Nucleotide

• Length: 291 bp

>T183743 NZ_CP087171:c1768182-1767607 [Pseudomonas atacamensis]
GTGAGGCATTCCTCTTTCACTGCTGTATACGATGCATGCGTTTTATATCCGGCCCCTTTAAGAGATTTCCTGATGTGGCT
CGCGTTGTCAGGGCTGTATCGGGCTCGCTGGACTCAGGAAATACACCACGAATGGAAGCGTAACTTATTGAAGAACAGGT
CCGACCTGACCCTCGAACAACTCGATCGCACATCGCAATTGATGGACCTGGCCATTCCAGACGCGTGTATCGATGGCTAT
GAAGACTTGGTGTCAGGCCTGACACTGCCTGATGAGAACGACCGCCATGTTCTAGCGGCCGCAATCCGATGCGGTGCCGA
TGTAATAGTGACGTTCAACCTGAAAGATTTCCCCACCCGTCACCTCGCGCCATACGGCATTGAAGCTCAGCACCCGGATG
AGTTTGTGGAAAACCTTTTCCATCTTGATTCGGCTGCCGTCGTCGCTGCGGCTCAAAGCCAGCGACGGCAATTGAAAACC
CCCAATGTGGAGGTGGACAAATATCTTGGTTTTCTCCAACGGCAAGGATTGGTCGAGTCGGTAAAGGCGTTAGGTAACTA
TCGTGCGATTCTCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8553.38 Da
• Isoelectric Point: 4.0530

>AT183743 WP_198499160.1 NZ_CP065989:c3357743-3357510 [Brevibacterium casei]
MAQNTSISLDDHFVDFLSQEVASGRYQSASEVVRAGLRMLEDHETQMATLRAALIAGEESGEPEDFDFEEFIAAKRS

Nucleotide

• Length: 234 bp

>AT183743 NZ_CP087171:c1768646-1768179 [Pseudomonas atacamensis]
ATGACCACCGCTACTCCATCTGCCATCAATCTGCCTGTCGAACGCGAGGTCAAAGCCGCGATTGAAGGCCAGCGCGCCCT
GAGCGCCTTCCTCACAACCGCTTTTGAAACTCAGAGAATCCAGATTTTTGATGAACAGAACGAAGCCCACAGCGTGGAGC
TGCCAACATCGGCATTACGCTTGCTGAGCGATATCCTCGCGGCGCTGGCGCAGGGCAACGCTGTGAAGGTGGTACCGATC
CACGCGGAGCTGACCACGCAGGAAGCTGCCGATCTGCTCAACGTCTCACGTCCGCACATGATCAAACTGCTGGAGAGGGG
TGAGATTTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGAATATAAAACCCGGCGAGACA
CCGCCAGCGAGCAGGCAATGACGCTTCTCGCGGAGCAGGCACAGGCGCTAAGGACAGGATACGAGTGA