Detailed information of TA system TA183741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1430952..1432510
• Replicon: chromosome
• Accession: NZ_CP065983
• Organism: Aggregatibacter segnis strain FDAARGOS_987

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6H44_RS07030
• Protein ID: WP_081456144.1
• Coordinates: 1430952..1432232 (-)
• Length: 427 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: E6KYQ8
• Locus tag: I6H44_RS07035
• Protein ID: WP_006718865.1
• Coordinates: 1432232..1432510 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H44_RS07010	1426135..1427052	+	918	WP_006718876.1	restriction endonuclease	-
I6H44_RS07015	1427109..1430036	+	2928	WP_006718874.1	valine--tRNA ligase	-
I6H44_RS07020	1430084..1430491	+	408	WP_006718872.1	(deoxy)nucleoside triphosphate pyrophosphohydrolase	-
I6H44_RS07025	1430478..1430873	+	396	WP_006718869.1	HNH endonuclease	-
I6H44_RS07030	1430952..1432232	-	1281	WP_081456144.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6H44_RS07035	1432232..1432510	-	279	WP_006718865.1	helix-turn-helix domain-containing protein	Antitoxin
I6H44_RS07040	1432663..1433718	-	1056	WP_006718863.1	ABC transporter substrate-binding protein	-
I6H44_RS07045	1433971..1435485	-	1515	WP_006718861.1	DHA2 family efflux MFS transporter permease subunit	-
I6H44_RS07050	1435498..1436658	-	1161	WP_006718859.1	EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit	-
I6H44_RS07055	1436849..1437331	+	483	WP_006718857.1	DNA starvation/stationary phase protection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1430084..1441542	11458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-64)

Sequences

Toxin

Protein

• Length: 427 a.a.
• Molecular weight: 49143.45 Da
• Isoelectric Point: 8.5442

>T183741 WP_081456144.1 NZ_CP065983:c1432232-1430952 [Aggregatibacter segnis]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLKGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLINHNGLQKQKVKMAMAWHGKNKHYLWDKIQPRHIFNTAKLAGLSKETVEDVLHEISALYRRVSE
INTHGLPDEIVEPILMGLEMQMKKIS

Nucleotide

• Length: 1281 bp

>T183741 NZ_CP087171:467490-467852 [Pseudomonas atacamensis]
ATGGTGCGCCGACAGCCCCCTCAGCGGGGTGACGTTTACTGGATTGATCCAAACCCAGTGGCGGGGCGGGAGATGATGAA
CAGACATCGCTTTGTGGTGATCACGCCCAGAGAGATCAACGCATTGGGCGTGAGCATGACGGTGCCTGTTACTAGCGGTG
AGAATTTCAGCCGGAATATGGGTTTGGCGGTCGCCATTACTGGCCACGAAACCAATGGTGTAGCGGTGTGTAATCAGGTT
CGCAGTTTTGACATAGAACAACGGGTACGAGACGGCACGGCCAAATTCATCGAGCGACTGGATGACGTGACAATGTCTGA
CATCGTCGACCGTGTAATCAGTGCAATCGACCCGCTAAGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10370.82 Da
• Isoelectric Point: 5.1425

>AT183741 WP_006718865.1 NZ_CP065983:c1432510-1432232 [Aggregatibacter segnis]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSNTALSIK
EPTATYDDDEAW

Nucleotide

• Length: 279 bp

>AT183741 NZ_CP087171:467221-467490 [Pseudomonas atacamensis]
ATGTCCGTAACTTCCAAGATACGCCGCCAAGGCGGCGCTGCCGTCATTACGATTCCGCCCACGCTTTTAAAGTTGTTGCA
TCTGGAGGTTGGCGCACAGCTAGAGCTGAATGTGGTCGATGGCGAACTGATTGCTCGTCCAGCCGTAGCCGCTACGCGTA
AGCGTTATAGTTTGTCAGAGCTACTCGAAGGCGCAGAAGAATTGCAGAAACTTAACGCCCAGACTAGCGAGACCCTTGAA
GGTGATTCTGTCGGCCGGGAGCTGGGTTGA

Structures

Antitoxin

• AlphaFold DB: E6KYQ8