183740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1164925..1165416 Replicon chromosome
Accession NZ_CP065981
Organism Macrococcus caseolyticus strain FDAARGOS_1005

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I6H62_RS06330 Protein ID WP_101141631.1
Coordinates 1164925..1165275 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I6H62_RS06335 Protein ID WP_099482357.1
Coordinates 1165276..1165416 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H62_RS06305 1160033..1162168 - 2136 WP_133453581.1 RNA-binding transcriptional accessory protein -
I6H62_RS06310 1162245..1163012 - 768 WP_101141623.1 RNA polymerase sigma factor SigB -
I6H62_RS06315 1163017..1163460 - 444 WP_101141625.1 anti-sigma B factor RsbW -
I6H62_RS06320 1163465..1163788 - 324 WP_101141627.1 anti-sigma factor antagonist -
I6H62_RS06325 1163869..1164876 - 1008 WP_101141629.1 PP2C family protein-serine/threonine phosphatase -
I6H62_RS06330 1164925..1165275 - 351 WP_101141631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6H62_RS06335 1165276..1165416 - 141 WP_099482357.1 antitoxin MazE Antitoxin
I6H62_RS06340 1165477..1166619 - 1143 WP_101141633.1 alanine racemase -
I6H62_RS06345 1166645..1167001 - 357 WP_101141634.1 holo-ACP synthase -
I6H62_RS06350 1166943..1167464 - 522 WP_165980832.1 PH domain-containing protein -
I6H62_RS06355 1167448..1168959 - 1512 WP_101141638.1 PH domain-containing protein -
I6H62_RS06360 1168949..1169425 - 477 WP_101141640.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12726.89 Da        Isoelectric Point: 10.1643

>T183740 WP_101141631.1 NZ_CP065981:c1165275-1164925 [Macrococcus caseolyticus]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T183740 NZ_CP087171:c317413-317015 [Pseudomonas atacamensis]
ATGATCAAGTACATGCTGGATACAAATATCTGCATCTTCACCATCAAGAACAAACCACAAATTGTCCGGGAAGCCTTCAA
TCGACATTCCGGGCAGTTGTGCATCAGCGCTATCACGCTTATGGAGCTTATTTACGGTGCTGAAAAGTCGGCGGCCCCGG
AGAAAAATCTGGCAATTGTTGAAGGATTTGTCGCGCGACTGGATGTCTTGCCTTTCGATAACGACGCAGCCGCACAGGCC
GGGATGGTTCGATCTGAACTCGCGAAGGCTGGAACGCCGATCGGGCCATACGACCAAATGATCGCTGGCCACGCACGCTC
ACTTGGACTCATTGTAGTGACGAACAACGTACGGGAGTTTCAACGCGTTTCCGGTTTGCGAATCGAGGACTGGGTTTAA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5352.91 Da        Isoelectric Point: 3.6323

>AT183740 WP_099482357.1 NZ_CP065981:c1165416-1165276 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNYQTYTFDGE

Download         Length: 141 bp

>AT183740 NZ_CP087171:c317643-317413 [Pseudomonas atacamensis]
ATGGAGCAGACCACAATTTTCATGAGCAACAGAAGTCAGGCAGTCCGACTGCCAAAGGCAGTTGCGATGCCCGGCGACGT
TAAACGAGTGGAAGTCATCGCGATTGGCAGAACACGCGTCATTACGCCTGCTGGAGAAAGCTGGGATAGCTGGTTTGATG
GCGACAGCGTCAGCCCTGATTTCATGGCTAACCGTGAGCAACCCACTGAACAGGAGCGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References