Detailed information of TA system TA183738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1622172..1622941
• Replicon: chromosome
• Accession: NZ_CP065980
• Organism: Staphylococcus felis strain FDAARGOS_1014

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6H71_RS07820
• Protein ID: WP_167389000.1
• Coordinates: 1622789..1622941 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: I6H71_RS07815
• Protein ID: WP_103208491.1
• Coordinates: 1622172..1622771 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H71_RS07795	1617977..1619431	+	1455	WP_103208483.1	ABC transporter substrate-binding protein/permease	-
I6H71_RS07800	1619424..1620146	+	723	WP_103208485.1	amino acid ABC transporter ATP-binding protein	-
I6H71_RS07805	1620448..1621575	+	1128	WP_103208487.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6H71_RS07810	1621578..1622048	+	471	WP_103208489.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6H71_RS07815	1622172..1622771	+	600	WP_103208491.1	glucosamine-6-phosphate isomerase	Antitoxin
I6H71_RS07820	1622789..1622941	+	153	WP_167389000.1	hypothetical protein	Toxin
I6H71_RS07825	1623054..1623452	+	399	WP_103208493.1	hypothetical protein	-
I6H71_RS07830	1623615..1625000	+	1386	WP_103208495.1	class II fumarate hydratase	-
I6H71_RS07835	1625022..1626548	+	1527	WP_103208497.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-197)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5983.40 Da
• Isoelectric Point: 3.9129

>T183738 WP_167389000.1 NZ_CP065980:1622789-1622941 [Staphylococcus felis]
MYQDKKDYDNEMVDGFDDMVELGKEMEQISEENDQEKLNQDHNQAVRSDK

Nucleotide

• Length: 153 bp

>T183738 NZ_CP087170:3607306-3607593 [Pseudomonas rhodesiae]
ATGGCCGCTGAGTACGAGGTTGAGTGGGATCCGAAGGCACTGAAGGAGTTGCGTAAACTCGACGGAACAATACGCCTCCA
GTTTCTGAAAAAGCTCCAGGAGCGGCAGTCCGGCCCGCGAGTGCCAGGCGATGCGCTTCATGGCATGAAGGACTGCTACA
AGATCAAATTGCGCGGCGCCGGCTACCGACTTGTGTACCGCGTTGAGGATGAGCGAATTGTCATCCTGGTGCTGGCTGTC
GGCAAACGCGAGCGAAGCTCTGTGTATGAGCAGGCGGGGAAGCGGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22340.43 Da
• Isoelectric Point: 5.8847

>AT183738 WP_103208491.1 NZ_CP065980:1622172-1622771 [Staphylococcus felis]
MAMNFKIFKDADTAALYTADIIRKQFNNNPTTIAGIHLNNEDAPVLEALKKSVDDHAVDFSQIHILDYDKKTSYYKALGV
PEKQVHEIAEEEQVESFIEHHAKTKNNKGKLTLQVVTIDQKGYLGVGMKEGILPAREIILVITGDYKADLVKKLYEENGN
TSFIPSTLKQHRMVNVVLDEAAAQGLPEDVRSYFTSLYA

Nucleotide

• Length: 600 bp

>AT183738 NZ_CP087170:3607029-3607316 [Pseudomonas rhodesiae]
ATGCAAAATATTCTGGCTGATGTGGCCGTCAGCGTATCTGAACTCAAGAAGAACCCCTCCTCCGTCTTGAGCGGCGCCAA
CGGCATGCCTGTGGCTGTGCTGAACCACAACCGCGTTATGGGCTACATGGTTCCAGCGAACGTCTACGAGGCGATGGTTG
AGCGCCTGGACGAACTGGAGCTGGTCCAACTAGTCAAGGCTCGGCTCGATGCTAAAGAAACACCTGTTCGGGTATCTCTG
GACGATCTGATTGGCGAGACAGAGGCAGATATCGCCAATGGCCGCTGA