Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1414446..1414976 Replicon chromosome
Accession NZ_CP065980
Organism Staphylococcus felis strain FDAARGOS_1014

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I6H71_RS06610 Protein ID WP_103207265.1
Coordinates 1414617..1414976 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I6H71_RS06605 Protein ID WP_103207266.1
Coordinates 1414446..1414616 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H71_RS06580 1410226..1410699 + 474 WP_103207274.1 PH domain-containing protein -
I6H71_RS06585 1410692..1412209 + 1518 WP_103207272.1 PH domain-containing protein -
I6H71_RS06590 1412190..1412735 + 546 WP_103207271.1 PH domain-containing protein -
I6H71_RS06595 1412732..1413088 + 357 WP_103207269.1 holo-ACP synthase -
I6H71_RS06600 1413216..1414364 + 1149 WP_103207268.1 alanine racemase -
I6H71_RS06605 1414446..1414616 + 171 WP_103207266.1 antitoxin MazE Antitoxin
I6H71_RS06610 1414617..1414976 + 360 WP_103207265.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6H71_RS06615 1415223..1416227 + 1005 WP_103207263.1 PP2C family protein-serine/threonine phosphatase -
I6H71_RS06620 1416305..1416631 + 327 WP_103207262.1 anti-sigma factor antagonist -
I6H71_RS06625 1416634..1417113 + 480 WP_103207378.1 anti-sigma B factor RsbW -
I6H71_RS06630 1417088..1417858 + 771 WP_103207260.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13331.49 Da        Isoelectric Point: 10.1421

>T183737 WP_103207265.1 NZ_CP065980:1414617-1414976 [Staphylococcus felis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKQKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDEKMKEVNNALGISLGLHMNQSKKD

Download         Length: 360 bp

>T183737 NZ_CP087170:c3603088-3602744 [Pseudomonas rhodesiae]
ATGAAAACAGTCTTCTTTGAAACGACAAGCTTCACCGCCACGGTAGGTGACTATCTGACTGACGATGAATATCGGCAGCT
CCAGACGGAAATGCAGGCGAATCCTGAAGCCGGTGATGTAATGCCACGTACCGGTGGCTTCAGAAAGCTTCGCTGGCAGG
ACACTCGCCGCGGGAAGGGCAAGCGTGGTGGTCTTCGTGTGATTTATTACTGGCTGCTCAATGACGGCCAGTTCTGGATG
TTTTCGATTTATGACAAGGATGAGATGGCGAACCTGACTGCTGCTCAGGAGAAGGCATTGAAGGCCGCTATAGATGCAGA
GCTGAAAAAACGAGGTGGGAAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6337.91 Da        Isoelectric Point: 4.0644

>AT183737 WP_103207266.1 NZ_CP065980:1414446-1414616 [Staphylococcus felis]
MSTFNQTRFKNNLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLTNSKDD

Download         Length: 171 bp

>AT183737 NZ_CP087170:c3602747-3602430 [Pseudomonas rhodesiae]
ATGAAAAAGAAGCGCGATCTGTTTGCTGAGCTGATGCAAGGCGTAAACGAGATGGGCGAGCACCGGCAGGGGAAGATCAC
ACTTCGACAGTACGAAGTGGAGGCTCTTTCACCTCCAGAGGTGACGGCTGCTGAGATCGTTTCCATCCGTGAGAATCTTC
ACATGTCGCAGCCAGTGTTCGCCCGGCAAATCAGGACGAGCCCCGACACGCTGAAGAACTGGGAGCAATCGAAGTCCAAG
CCAAATGCCCAGGCGGCGCTGCTGATTAAGTTGGTTCAGCGCTTCCCTGACATGGTTGAGCGACTCAACGCCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References