Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1400972..1401496 Replicon chromosome
Accession NZ_CP065980
Organism Staphylococcus felis strain FDAARGOS_1014

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag I6H71_RS06540 Protein ID WP_103207283.1
Coordinates 1401272..1401496 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag I6H71_RS06535 Protein ID WP_103207284.1
Coordinates 1400972..1401259 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H71_RS06510 1396137..1396928 + 792 WP_103207292.1 hydroxyethylthiazole kinase -
I6H71_RS06515 1396931..1397569 + 639 WP_103207290.1 thiamine phosphate synthase -
I6H71_RS06520 1397657..1398517 + 861 WP_103207289.1 membrane protein insertase YidC -
I6H71_RS06525 1398685..1399332 - 648 WP_103207287.1 HD domain-containing protein -
I6H71_RS06530 1399348..1400838 - 1491 WP_103207286.1 cardiolipin synthase -
I6H71_RS06535 1400972..1401259 + 288 WP_103207284.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6H71_RS06540 1401272..1401496 + 225 WP_103207283.1 cation transporter Toxin
I6H71_RS06545 1401498..1401704 + 207 WP_103207281.1 cation transporter -
I6H71_RS06550 1401834..1404020 + 2187 WP_103207380.1 heavy metal translocating P-type ATPase -
I6H71_RS06555 1404109..1404249 + 141 WP_167388982.1 hypothetical protein -
I6H71_RS06560 1404383..1405579 - 1197 WP_103207280.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(6-64)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8430.43 Da        Isoelectric Point: 4.1429

>T183736 WP_103207283.1 NZ_CP065980:1401272-1401496 [Staphylococcus felis]
MYQSYVQVSNIHTENDKEALEKRLSSMIGVLDVQIDINQQCVNLEYETPANLNTLEKEIYDAGFPVINSFKGGY

Download         Length: 225 bp

>T183736 NZ_CP087170:c2293269-2293018 [Pseudomonas rhodesiae]
GTGTCCAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAGCAAATGGCATTTACATGGCCCGAACTCGTCACGCTGCT
GCGTCGCCTGGGCTACACACAGATCGAAGGGGCTGGAAGCCGCGTCAAGTTCGACAGTGGCGACCCCACTGCCATGATCA
CGCTGCACAAGCCTCACCCTGGCAACGAACTGAAGCACTACATTCGACGCCAGATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11005.63 Da        Isoelectric Point: 6.8618

>AT183736 WP_103207284.1 NZ_CP065980:1400972-1401259 [Staphylococcus felis]
MTEQAHHSDSIKRNLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDYHMKGCIMHKIENGSEQE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183736 NZ_CP087170:c2293021-2292659 [Pseudomonas rhodesiae]
GTGAACAACCAACTCAAACACAAAGGCTACATCGGCTCTATCGAGGCCAGCCTTGAAGACAACTGCCTGTTCGGCAAGAT
CTTGTTCATCAAGGCGCTGATCAGCTACGAAGGAAAAACCGTCGCTGATTTGGATGCCGCTTTTCAGGCGGCCGTGGACG
ACTATCTCGTGACGTGCCAGAACCTTGGTCAAACCCCGGAAAAGCCATGCAAGGGCTCTTTCAATGTGCGGGTTGGACAT
GACCTGCATTTGGCTGCGGCGCTGGCGGCGACCCGCAAGAAAGTCACGCTCAATGACCTGACGCGTCAGGCGCTGAGTGA
GTTCCTGCAACATCACTTCGCAGAACTTCACCCCAGCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References