Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4159648..4160449 Replicon chromosome
Accession NZ_CP065970
Organism Escherichia coli strain FDAARGOS_1058

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag I6I15_RS20570 Protein ID WP_000854739.1
Coordinates 4159648..4160028 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I6I15_RS20575 Protein ID WP_001285482.1
Coordinates 4160075..4160449 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I15_RS20540 4156320..4157024 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
I6I15_RS20545 4157309..4157527 + 219 WP_001040187.1 translation initiation factor IF-1 -
I6I15_RS20555 4158034..4158861 - 828 WP_001304477.1 DUF4942 domain-containing protein -
I6I15_RS20560 4158946..4159143 - 198 WP_000772027.1 DUF957 domain-containing protein -
I6I15_RS20565 4159163..4159651 - 489 WP_001054232.1 hypothetical protein -
I6I15_RS20570 4159648..4160028 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
I6I15_RS20575 4160075..4160449 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6I15_RS20580 4160499..4161143 - 645 WP_000086763.1 hypothetical protein -
I6I15_RS20585 4161162..4161383 - 222 WP_000692315.1 DUF987 domain-containing protein -
I6I15_RS20590 4161446..4161922 - 477 WP_001186170.1 RadC family protein -
I6I15_RS20595 4161938..4162411 - 474 WP_000855076.1 antirestriction protein -
I6I15_RS20600 4162674..4163495 - 822 WP_001234710.1 DUF945 domain-containing protein -
I6I15_RS20605 4163576..4163787 + 212 Protein_3907 hypothetical protein -
I6I15_RS20610 4163906..4164361 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T183725 WP_000854739.1 NZ_CP065970:c4160028-4159648 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T183725 NZ_CP087168:3677577-3677927 [Pseudomonas sp. B21-048]
ATGGACGCTCTTTTTATCGAATTACCCGTATTTCAAAAGCATCGAAGTGACTACCTGGATGATGATCTGTTTCACCGGTT
CCAGCAGGAGCTGCTGCAAACCCCGGAAGCGGGAGATGTCGTCGAAGGCACCGGAGGTCTGCGCAAAATTCGAGTGGTGG
ATGAGCGGCGAAGCAAGGGCAAGCGCGGTGGGCTGAGGGTAATTTATTACTGGTGGTCCGGTTTCGACCAATTCTGGCTC
TTTACCTTGTATGGCAAGAACGAGCAGGACGATCTGACGCCACAACAGAAAAAACTGCTTAAAGAAATGCTTTATCGAGA
AATCAAAGCGAGAACGAGCGATGAAACGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT183725 WP_001285482.1 NZ_CP065970:c4160449-4160075 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT183725 NZ_CP087168:3677917-3678231 [Pseudomonas sp. B21-048]
ATGAAACGTGACATTTTTTCCGAGCTGGTAGAGGGGTTTGAAGCCTTGGCCGATGAGCGCCAAGGTAAAGTCACTCTACG
CACGCACAAAGTAAAACTGGCCAAGCTGGCTCCGATTACGGCAGAGGAAGTGGTTGGCATCCGCCAGCAACTGAATCTCT
CCCGGCCGGTGTTTGCGATGTACTTGCGCACCAACACCCGGACGCTGGAGAACTGGGAGCAAGGACGGGCGAAACCTAAT
GCTCAGGCGACAACGCTGATCCGGCTGGTTGAGCGCTTTCCGGAGACGGTTCAACAACTGGCGGCGCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References