Detailed information of TA system TA183724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3439422..3441010
• Replicon: chromosome
• Accession: NZ_CP065970
• Organism: Escherichia coli strain FDAARGOS_1058

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6I15_RS17015
• Protein ID: WP_097444381.1
• Coordinates: 3439688..3441010 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6I15_RS17010
• Protein ID: WP_001296726.1
• Coordinates: 3439422..3439688 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I15_RS17010	3439422..3439688	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6I15_RS17015	3439688..3441010	+	1323	WP_097444381.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
I6I15_RS17020	3441322..3441530	+	209	Protein_3201	helix-turn-helix transcriptional regulator	-
I6I15_RS17025	3441962..3442525	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
I6I15_RS17030	3442886..3443596	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	3439422..3455510	16088

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49378.04 Da
• Isoelectric Point: 9.3124

>T183724 WP_097444381.1 NZ_CP065970:3439688-3441010 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENAFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T183724 NZ_CP087168:1564426-1564638 [Pseudomonas sp. B21-048]
GTGCAGAGCAGGTTATTGATCAAGGAACTGATAGAGGCGGGCTGGACACTGGACCGGGTCACCGGCAGTCATCACCTCTT
CACTCACCGTTACAACCCTTACACGATACCCGTCCCTCATCCGAAGAAGGATTTGCCGATCGGGACGATCAAAAGCATCA
GGAGGCGAGCCGGGCTTTATTGCCCGGGAGCCAGTTTGGCAGGAGATCCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT183724 WP_001296726.1 NZ_CP065970:3439422-3439688 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT183724 NZ_CP087168:1564638-1565042 [Pseudomonas sp. B21-048]
ATGCAATACCCAATCTGTATCGAGTGGGGCGACGAGAACACCGCCATCGGTATTCAGATCCCCGATATTCCGGGTGCCGT
AACGGCCGGGGATACGTTTGAAGATGCTTACAATGCGGCGGTTGAAATTGCCCACATCATGCTGCAGGAGATCATGGCAG
ACGGGGAGTCCATTCCTATGCCGACCTCAGCGGCTGCGCACCGCGAGAATCCGGAATTTGCCGACATGGGTTGGGGGATG
CTGGAACTCGACATCTCGCCGTATCTGGGCAAGACCGAGAAGGTCAACGTGACGCTGCCTGGCTACGTGATCCAGCGCAT
TGACCGCTATGTGCGAGAGCACAATGTCAAAAGCCGCTCCTCCTTTCTCGCGGATGCGGCAATGGAGAAGCTGATTCGAC
ATTGA