Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 283752..284347 Replicon chromosome
Accession NZ_CP065970
Organism Escherichia coli strain FDAARGOS_1058

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag I6I15_RS01885 Protein ID WP_000239579.1
Coordinates 283752..284102 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag I6I15_RS01890 Protein ID WP_001223208.1
Coordinates 284096..284347 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I15_RS01865 279028..280050 - 1023 WP_001339490.1 ABC transporter permease -
I6I15_RS01870 280064..281566 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
I6I15_RS01875 281876..282832 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6I15_RS01880 283142..283672 + 531 WP_094250134.1 inorganic diphosphatase -
I6I15_RS01885 283752..284102 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
I6I15_RS01890 284096..284347 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6I15_RS01895 284560..284901 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6I15_RS01900 284904..288683 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T183704 WP_000239579.1 NZ_CP065970:c284102-283752 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T183704 NZ_CP087165:c4057596-4057300 [Pseudomonas sichuanensis]
ATGGAAAAGAGAGTGCCTCATTGTCCACTTGATCGGGTAAAAGCGCTGCTTGCTGTGAAGCGGGTCAGTCCGACCTTCGC
TGCATTAAGAGGTGCCAGGTCTCTGGGCCTGGATTACCCAGGAATGCTCGATGTAATCAGCAGTCTGGAACGCACGGATT
TTTACAAAAGCATGAGCTGCTATACGGAGCACCGCGTCTGGCAGGACGTATACCGTCCGCTCACGGCAGTCGGCTACGTT
TACCTGAAACTGTCAGTGGTCGATGACGTGCTCATCGTGTCCTTCAAGGAGCTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT183704 WP_001223208.1 NZ_CP065970:c284347-284096 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT183704 NZ_CP087165:c4057297-4056896 [Pseudomonas sichuanensis]
ATGAGATGCCCAATCTGTGGCGCTGCGGAGCTTGCGCCAGATATTCAGGATATGCCCTACCGCTACAAAGGAGAGTCGAC
TCTGATCCAGGGCGTCAGCGGCGATTACTGCTCTGCCTGTGGTGAGGCGGTCCTGAGCCACGACGAAGCCATGCGTGTCA
GTGAGCAGATGACGGCCTTTGAGCGTCGGGTCAATGCGACTGCGGTCGATCCAGCTTTCATCAGCGCCGTGCGCAAGAAA
TTTGACCTGGACCAGCGCGAGGCAGGTGAGATTTTCGGTGGTGGGGTCAACGCTTTTTCCCGCTACGAAAATGGTAAAAC
CACGCCGCCAGTGGCGTTGATCAAGCTGTTCAAGCTGCTCGACCGCCACCCCGAGCTGTTCGAGGAAGTCAGGACCGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References