Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 6279890..6280932 | Replicon | chromosome |
| Accession | NZ_CP065966 | ||
| Organism | Pseudomonas aeruginosa strain FDAARGOS_1041 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | I6H98_RS29755 | Protein ID | WP_003153636.1 |
| Coordinates | 6280357..6280932 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | I6H98_RS29750 | Protein ID | WP_003050245.1 |
| Coordinates | 6279890..6280360 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6H98_RS29715 | 6275282..6276700 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| I6H98_RS29720 | 6276690..6277601 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| I6H98_RS29725 | 6277598..6278290 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| I6H98_RS29730 | 6278287..6278685 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| I6H98_RS29735 | 6278697..6279056 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| I6H98_RS29740 | 6279073..6279306 | - | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
| I6H98_RS29745 | 6279303..6279686 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| I6H98_RS29750 | 6279890..6280360 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I6H98_RS29755 | 6280357..6280932 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| I6H98_RS29760 | 6280950..6281864 | + | 915 | WP_016852809.1 | AAA family ATPase | - |
| I6H98_RS29765 | 6281861..6282331 | + | 471 | WP_003090160.1 | hypothetical protein | - |
| I6H98_RS29770 | 6282328..6282828 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| I6H98_RS29775 | 6282828..6283730 | + | 903 | WP_003090158.1 | nucleotidyltransferase domain-containing protein | - |
| I6H98_RS29780 | 6283769..6284494 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 6205326..6327030 | 121704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T183701 WP_003153636.1 NZ_CP065966:6280357-6280932 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T183701 NZ_CP087165:c1122570-1122250 [Pseudomonas sichuanensis]
ATGCTTTTTACCGAAACCGCTGTCTTTACCAAACGCGCAAAAGAGCTGCTCGACGACGAAACCTACAGGTTGTTGCAGGT
TCGTCTTTTGATATCCCCCGATGCAGGGGATGTCATCGAAGGGACCGGCGGCCTGCGCAAAATCCGCGCCCCAGCGAATG
GCCACGGCAAGCGAGGCGGCGCCAGAGTCATCTACTACCACTTCACGGCAAGGTCACATATCACCTTGCTCTACATCTTT
GCGAAGAACGAACAAACGGAGCTATCCGCCGAACAGCGCAAGGCTTTGAAGTCCGTCATCGAAAACTGGAGATACCCATG
A
ATGCTTTTTACCGAAACCGCTGTCTTTACCAAACGCGCAAAAGAGCTGCTCGACGACGAAACCTACAGGTTGTTGCAGGT
TCGTCTTTTGATATCCCCCGATGCAGGGGATGTCATCGAAGGGACCGGCGGCCTGCGCAAAATCCGCGCCCCAGCGAATG
GCCACGGCAAGCGAGGCGGCGCCAGAGTCATCTACTACCACTTCACGGCAAGGTCACATATCACCTTGCTCTACATCTTT
GCGAAGAACGAACAAACGGAGCTATCCGCCGAACAGCGCAAGGCTTTGAAGTCCGTCATCGAAAACTGGAGATACCCATG
A
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT183701 WP_003050245.1 NZ_CP065966:6279890-6280360 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT183701 NZ_CP087165:c1122253-1121966 [Pseudomonas sichuanensis]
ATGAGCCGCCTCTTCGACGAACTGATGGAAAGCGTTGTAGAAATGGATGAAATCATCCAGGGCAAACGCCAACCCTCGCG
CCAGTTCGAAATCGACGCCCTGCAAGTCCGGGAAATCCGCAAGGCCACCGGTTTGTCACAGGTACGTTTCGCCGAGATGA
TCGATGTGCAAGTCGCTACGCTGCGTAACTGGGAACAGGGGCGCCGGGAGCCCACGGGGCCTGCCAAAGCGCTGCTGCGG
GCCATCCACAACGACCCTGATCACGTGCTCAAGGCCTTGTCGCATTGA
ATGAGCCGCCTCTTCGACGAACTGATGGAAAGCGTTGTAGAAATGGATGAAATCATCCAGGGCAAACGCCAACCCTCGCG
CCAGTTCGAAATCGACGCCCTGCAAGTCCGGGAAATCCGCAAGGCCACCGGTTTGTCACAGGTACGTTTCGCCGAGATGA
TCGATGTGCAAGTCGCTACGCTGCGTAACTGGGAACAGGGGCGCCGGGAGCCCACGGGGCCTGCCAAAGCGCTGCTGCGG
GCCATCCACAACGACCCTGATCACGTGCTCAAGGCCTTGTCGCATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|