183700

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5397599..5399107 Replicon chromosome
Accession NZ_CP065966
Organism Pseudomonas aeruginosa strain FDAARGOS_1041

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag I6H98_RS25385 Protein ID WP_003119682.1
Coordinates 5397599..5398186 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag I6H98_RS25390 Protein ID WP_003119683.1
Coordinates 5398253..5399107 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H98_RS25380 5393854..5397333 - 3480 WP_003117605.1 hybrid sensor histidine kinase/response regulator -
I6H98_RS25385 5397599..5398186 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
I6H98_RS25390 5398253..5399107 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
I6H98_RS25395 5399204..5401369 + 2166 WP_016852624.1 TonB-dependent receptor family protein -
I6H98_RS25400 5401544..5403418 + 1875 WP_003117607.1 MFS transporter -
I6H98_RS25405 5403479..5403688 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T183700 WP_003119682.1 NZ_CP065966:5397599-5398186 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T183700 NZ_CP087165:293751-293942 [Pseudomonas sichuanensis]
ATGAACAGCCGCGAAATGATCTCGGTGATCGAGGCCGATGGTTGGTACCTGGTGCGATCCAAGGGCAGCCACCATCACTT
CAAGCACCCCCAAAAGACTGGGCTGGTGACCATCCCGCACCCGAAGAAGGACCTGCTGCCCGCCACTGCGGCCAGCATCC
TGCGCCAGGCGCGGATCGGTTACGCCAGCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT183700 WP_003119683.1 NZ_CP065966:5398253-5399107 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT183700 NZ_CP087165:293960-294373 [Pseudomonas sichuanensis]
ATGTTATTCCCCATCGCCATCCTGCCCGGCGACGACCAGCACGCCTGGGGCGTGGAAGTCCCGGACATCCCCGGCTGCTT
TTCGGCCGGTGAAGACCTCGATGACGCCATCGCCATGGCCCGCGAGGCCATCGAGGGCCACCTCGAACTGCTCGCCCAGG
ACGGCCAGGAAATCCCCAAGGCCAGCAAGGTGAGCGTCCATGCGGCCAACCCTGACTACGCCGGATGCACCTGGGCACTC
ATCGACATCGATATCACCCGCTACCTGGGCAAGGCCGAGAAGCTCAACATCACCCTGCCGGCCTACCTGCTCACCCGCAT
CGATGCCTACGTGAAGAACCATCCGGAGCAGAAAAGCCGCTCGGGCTTCCTGGCTGAAGCGGCGCTGAGAATCCTGCAGG
GCGACTGCAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References