183699

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3737250..3737755 Replicon chromosome
Accession NZ_CP065966
Organism Pseudomonas aeruginosa strain FDAARGOS_1041

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag I6H98_RS17435 Protein ID WP_003121619.1
Coordinates 3737250..3737531 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag I6H98_RS17440 Protein ID WP_003112628.1
Coordinates 3737528..3737755 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H98_RS17410 3732501..3733850 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
I6H98_RS17415 3733899..3734585 + 687 WP_003083762.1 FadR family transcriptional regulator -
I6H98_RS17420 3734686..3735420 + 735 WP_003117208.1 GntR family transcriptional regulator -
I6H98_RS17425 3735624..3736010 + 387 WP_014602345.1 aegerolysin family protein -
I6H98_RS17430 3736042..3736950 - 909 WP_016561475.1 LysR family transcriptional regulator -
I6H98_RS17435 3737250..3737531 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
I6H98_RS17440 3737528..3737755 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
I6H98_RS17445 3737931..3738551 - 621 WP_003101226.1 hypothetical protein -
I6H98_RS17450 3738652..3739152 + 501 WP_003112629.1 LEA type 2 family protein -
I6H98_RS17455 3739225..3739566 + 342 WP_003101229.1 alkylphosphonate utilization protein -
I6H98_RS17460 3739648..3741075 - 1428 WP_003083784.1 GABA permease -
I6H98_RS17465 3741244..3742737 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T183699 WP_003121619.1 NZ_CP065966:c3737531-3737250 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T183699 NZ_CP087164:1080188-1080604 [Capillimicrobium parvum]
GTGGCTCTGCTGGACGTCAACGCGCTCGTCGCGCTGGCGTGGGACTCGCACGTGCATCACGCGGCGATCCGCCGATGGTT
CGCCACGAATGCCGCCGCCGGTTGGGCGACCTGCCCGGTGACGGAGAGCGGGTTCGTGCGCGTCTCGTCGAACCGGCGAG
CGCTGCCGAGCGCGATCGGAGCCGAGGCGGCCCGGGGGGTTCTCGCGGCGATGCGCACCGTGGAGGGCCATCGGTTCGTC
CCCGACGACGTCTCGGTGACGGACCCGGACGTCCCGCCGCTGCACGGTCACCGGCAGGTCACCGACGCCCACCTCCTCGT
TCTGGCGCGGCGCAACGACCTACGCGTGGTGACGTTCGACGCCGGTCTCGCGGCATTGGCGGAGGGTCGCGGCGTGGAGT
TGCTGACGGTCCTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT183699 WP_003112628.1 NZ_CP065966:c3737755-3737528 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT183699 NZ_CP087164:1079958-1080179 [Capillimicrobium parvum]
ATGCGCACCACGCTCGACATCGACGCGGACGTGGTCGCCGCTGCTCGGGAGCTCGCGGCGGCCGAGCGGCGGTCGCTCGG
CTCGGTCATCTCAGAGCTCGCACGCCGCGGGCTCAGCCCGGCCCGGGTCGAGTCTGGCGGCGACCTCCCCGTCATCCGCG
TGCCACTGGGCACCGCGCCGATCACCCCCGAGATGGTCCGCCGCGCCCTCGACGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References