Detailed information of TA system TA183695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1405968..1407226
• Replicon: chromosome
• Accession: NZ_CP065966
• Organism: Pseudomonas aeruginosa strain FDAARGOS_1041

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: I6H98_RS06545
• Protein ID: WP_003112528.1
• Coordinates: 1405968..1406723 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: I6H98_RS06550
• Protein ID: WP_003086329.1
• Coordinates: 1406858..1407226 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H98_RS06535	1401141..1403684	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
I6H98_RS06540	1403839..1405200	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
I6H98_RS06545	1405968..1406723	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
I6H98_RS06550	1406858..1407226	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
I6H98_RS06555	1407299..1408585	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
I6H98_RS06560	1408641..1410230	-	1590	WP_003125055.1	aldehyde dehydrogenase family protein	-
I6H98_RS06565	1410309..1410785	+	477	WP_003112531.1	hypothetical protein	-
I6H98_RS06570	1410788..1411063	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T183695 WP_003112528.1 NZ_CP065966:c1406723-1405968 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T183695 NZ_CP087160:4752529-4752807 [Pseudomonas sp. CIP-10]
ATGATTCAAAGCTTTAGCTGTGCCGACACGGAAGCGCTCTTCACAACGGGAAAGACACGGCGCTGGTCAGATATCAAGTC
AGTCGCGGAGCGCAAACTGGCCACGCTCGATGCCGCAACAGAGTTGCGAGACCTTAGGTCGCCACCTGGCAATCGCCTCG
AGTCACTGAGCGGCAACCGCGCCGGCCAACACAGTATCCGTGTAAATGACCAATGGCGGTTGTGCTTCTCCTGGACAGAG
CACGGGCCAGTTAACGTTGAAATTGTCGATTACCACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT183695 WP_003086329.1 NZ_CP065966:c1407226-1406858 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT183695 NZ_CP087160:4752816-4753115 [Pseudomonas sp. CIP-10]
ATGCTCAAGAACGGTATGCGTCCAATCCATCCGGGTGAAATCCTGCGGGAGGACTTCCAAAAGGAAATGGGCTTCAGCGC
CGCGGCTCTGGCCAGGGCGTTGGGTGTAGCAACGCCAACCGTCAACAACATCCTGCGCGAACGGGGCGGTGTTTCCGCCG
ACATGGCACTGCGTCTGTCCATCTGCTTGGACACCACCCCTGAGTTCTGGCTCAACCTGCAGACGGCCTTCGATCTGCGC
ACAGCCGAACAGCAACACGGCGATGAGATCATCGGGTCGGTCCAGCGCCTGGTCGCTTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7