Detailed information of TA system TA183694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 433185..434406
• Replicon: chromosome
• Accession: NZ_CP065966
• Organism: Pseudomonas aeruginosa strain FDAARGOS_1041

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6H98_RS01965
• Protein ID: WP_003114949.1
• Coordinates: 433828..434406 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6H98_RS01960
• Protein ID: WP_003088112.1
• Coordinates: 433185..433739 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H98_RS01935	428753..429304	+	552	WP_003102727.1	XRE family transcriptional regulator	-
I6H98_RS01940	429301..429699	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
I6H98_RS01945	429712..430035	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
I6H98_RS01950	430366..430827	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
I6H98_RS01955	430832..433027	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
I6H98_RS01960	433185..433739	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
I6H98_RS01965	433828..434406	+	579	WP_003114949.1	HD domain-containing protein	Toxin
I6H98_RS01970	434514..435701	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
I6H98_RS01975	435691..437862	-	2172	WP_016851733.1	type I secretion system permease/ATPase	-
I6H98_RS01980	437852..439129	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21897.75 Da
• Isoelectric Point: 5.3655

>T183694 WP_003114949.1 NZ_CP065966:433828-434406 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T183694 NZ_CP087160:c3836524-3836087 [Pseudomonas sp. CIP-10]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGTGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGGCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCTGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT183694 WP_003088112.1 NZ_CP065966:433185-433739 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT183694 NZ_CP087160:c3836970-3836521 [Pseudomonas sp. CIP-10]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGACTTCGAGATTCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGCTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTTGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA