Detailed information of TA system TA183693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 4823133..4824716
• Replicon: chromosome
• Accession: NZ_CP065965
• Organism: Stenotrophomonas maltophilia strain FDAARGOS_1044

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6I01_RS22465
• Protein ID: WP_038646246.1
• Coordinates: 4823133..4824455 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6I01_RS22470
• Protein ID: WP_005407534.1
• Coordinates: 4824459..4824716 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I01_RS22450	4818527..4820161	-	1635	WP_005407530.1	TldD/PmbA family protein	-
I6I01_RS22455	4820192..4821823	-	1632	WP_024956315.1	TldD/PmbA family protein	-
I6I01_RS22460	4822518..4823132	+	615	WP_038646249.1	DUF938 domain-containing protein	-
I6I01_RS22465	4823133..4824455	-	1323	WP_038646246.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6I01_RS22470	4824459..4824716	-	258	WP_005407534.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I01_RS22475	4824878..4828564	-	3687	WP_024956262.1	indolepyruvate ferredoxin oxidoreductase family protein	-
I6I01_RS22480	4828736..4829371	+	636	WP_024956261.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-70)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49039.94 Da
• Isoelectric Point: 6.9606

>T183693 WP_038646246.1 NZ_CP065965:c4824455-4823133 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Nucleotide

• Length: 1323 bp

>T183693 NZ_CP087160:c1948768-1948193 [Pseudomonas sp. CIP-10]
ATGAAGCACTCGCCCTTCACGGCCATATACGACGCGAATGTACTTTACCCTGCCCCACTGCGTGATTTCCTGATGAACCT
AGCGCTGACGGGCATCTACCGGGCACGTTGGTCAGCGAGCATTCATGACGAGTGGAAGCGCAATCTGCTACTCAACCGAC
CTGACCTCACGCCTGAACATTTGGATCGCACGTCATCGCTAATGGATGCTACGGTGCCTGATGCACTCGTCACTGACTAC
GATTCACTGGTCGAAGGGCTGGACTTGCCAGATCGGGATGATCGACATGTTCTCGCAGCTGCAATCAAGTGCAACGCTTC
GGTCATCGTCACCTTCAATTTGAAGGATTTTCCCAAGGCGGTTCTTGGTGCCTTCGATATTGAACCCTTGCATCCGGACG
ACTTCATCGCTGACCTTTGGGACCTGGACAAGGCAGCAGTCCTCGAAGCTGCCCAGCGGCAGCGAATATCGCTGAAGAAC
CCACCGCACAACGTACAGCAGTATCTCGACAGGCTGCTTCAGCAGAAGCTTCCCGAGACAGTGAAACTGCTTTCAGCATT
CAAGTTCCTCCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9584.97 Da
• Isoelectric Point: 11.8468

>AT183693 WP_005407534.1 NZ_CP065965:c4824716-4824459 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Nucleotide

• Length: 258 bp

>AT183693 NZ_CP087160:c1949232-1948765 [Pseudomonas sp. CIP-10]
ATGACCACCGCCAACCTCTCTCGCCATGTGCTTCCTGATGAGAAAGAAATTGCCGTGGCAGTCGAGTCAAGCCGCACGCT
GGCAGCGTTCCTCTCGACAAAATCAGATACCCAACGGATCGAACTGCTCAACGAGGAAAATCAGCGCCAGGTTGTTGAAG
TACCTACTTTCGCCCTACGCCTATTCGGCGAGATTCTCAGCGAACTGGCCCTGGGTAACTCAGTCAAAGTCGTTCCAATC
CACGCCGAACTAACTACCCAGGAAGCAGCAGACCTGCTTAACGTCTCCCGGCCGCACTTGGTAAAGCTGCTCGACGAAGC
GGTGATTCCGCACACCAAGACAGGCCGCCATCGTCGTGTCAAATTCTCCGACCTGGTTGCCTACAAGGACAAACGTGATG
GGGTGAGCCGGACTGCGATGGATGCGCTAGCAGCCCAAGCTCAGGAATTGAAGATGGGGTACGAATGA