Detailed information of TA system TA183690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Xre-MNT/HTH_26(antitoxin)
• Location: 2184299..2185407
• Replicon: chromosome
• Accession: NZ_CP065960
• Organism: Mammaliicoccus sciuri strain GDK8D55P

Toxin (Protein)

• Gene name: MNTss
• Uniprot ID: R3JIN1
• Locus tag: JCQ35_RS11265
• Protein ID: WP_000233000.1
• Coordinates: 2184299..2185168 (-)
• Length: 290 a.a.

Antitoxin (Protein)

• Gene name: Xress
• Uniprot ID: -
• Locus tag: JCQ35_RS11270
• Protein ID: WP_000205227.1
• Coordinates: 2185183..2185407 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCQ35_RS11235	2180722..2180760	-	39	WP_193221770.1	hypothetical protein	-
JCQ35_RS11240	2181550..2181753	-	204	WP_017370349.1	conjugal transfer protein	-
JCQ35_RS11245	2181837..2182517	+	681	WP_044291606.1	IS6-like element IS1216 family transposase	-
JCQ35_RS11250	2182573..2182644	-	72	Protein_2178	adenine phosphoribosyltransferase	-
JCQ35_RS11255	2182688..2183551	-	864	WP_002294505.1	aminoglycoside nucleotidyltransferase ANT(6)-Ia	-
JCQ35_RS11260	2183584..2184318	-	735	WP_000662263.1	class I SAM-dependent methyltransferase	-
JCQ35_RS11265	2184299..2185168	-	870	WP_000233000.1	nucleotidyltransferase domain-containing protein	Toxin
JCQ35_RS11270	2185183..2185407	-	225	WP_000205227.1	helix-turn-helix transcriptional regulator	Antitoxin
JCQ35_RS11275	2185550..2187094	-	1545	WP_002390960.1	recombinase family protein	-
JCQ35_RS11280	2187114..2187530	-	417	WP_000323438.1	recombinase	-
JCQ35_RS11285	2187531..2187827	-	297	WP_002360685.1	hypothetical protein	-
JCQ35_RS11290	2188375..2189538	-	1164	WP_025905227.1	chromate efflux transporter	-
JCQ35_RS11295	2189549..2189851	-	303	WP_025905228.1	helix-turn-helix transcriptional regulator	-
JCQ35_RS11300	2189977..2190378	-	402	WP_025905229.1	arsenate reductase (thioredoxin)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polymerase, nucleotidyl transferase domain (12-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-57)

Sequences

Toxin

Protein

• Length: 290 a.a.
• Molecular weight: 32926.57 Da
• Isoelectric Point: 4.8781

>T183690 WP_000233000.1 NZ_CP065960:c2185168-2184299 [Mammaliicoccus sciuri]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Nucleotide

• Length: 870 bp

>T183690 NZ_CP087156:c2967401-2966781 [Roseibium aggregatum]
ATGACAAAGACGCCCCCTTCCCTCGATCTTTCCGAAATTTCCCACACCAGACTGACAGGCCTGCTGGACTTCCTTCAGGC
TGCTGAGCAGCTGAAAGACACGCTTCGCTCGGGAACGACAACCGGCGGCAGGCCGGAGAGCACTGCCGAACATAGCTGGC
GACTGGCCTTGATGGTTCTGTTGTTCGAACCAGAGCTGAAAGAAATCGACATGCTCAAACTCCTGAAGCTGACGCTTGTG
CATGACCTGGGCGAAGCCATCTCCGGAGATGTCCCCGCTCCACTCCAGACGCCGGGTGACGACCGGCAGGAACGCGAGAG
GCGGGACTTCCTGACCTTGTGTGAACCGCTGCCGGGTGACGTGGCTGGGGAGCTAACCTCCCTCTGGGATGAGTATGCAG
CGGCACGAACCGTCGAAGCCCGACTTGCCAAGGCGTTCGACAAGCTGGAGACCATGCTTCAGCACGTTCTGATGCCAAGG
CAAGCGCCTTCATTTTATGAGTTCAACCTCGGTTACGGCCGTGATCGCACCGATTGCAGTGCTCTCACGCGCCAGTTGCG
GGACGAAGTCGACGAGCTGACCCGCACCATGATGACGGGCGCCGGACGGGAATTCGCCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.68 Da
• Isoelectric Point: 4.5510

>AT183690 WP_000205227.1 NZ_CP065960:c2185407-2185183 [Mammaliicoccus sciuri]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Nucleotide

• Length: 225 bp

>AT183690 NZ_CP087156:c2968020-2967451 [Roseibium aggregatum]
ATGCAAACAGAAACCGCCGTTCTTGAAAGCAGTCTTGGACCGTCGCTGCGGCGCTGGCGCGTACTGAACCGGGTCAAGCA
GGAAGCTCTGGCACATGAACTCGGCGTCTCGCAGACGAGGATATCGCGCTGGGAGAGTGGCAAGTCGCAGCCGGACGACA
GCGACAGGGCGAAGATCACCCGTCTGCTGAGGGCACGTCCGGAGAGCGCCGCCGACAAGGCCCTGCTTGATCTTGTTTCC
CGGTCCGCAGTTCCCGTGCATCTGGTCTGCGACCTCACACACAGGCTGCTGGCCATATCCGTACCGCGTGCCTGCGAATG
GCGCGCACCGGTGAACGAGTTTCTGAACCGGCCCCTGTGGCGTTTTGCGTCCGAAGGCATCCGGGCAACAGAGCACAGAC
TGACCGACTATGGCTGGTTCGAGCCGGATGCTCCGGACATTGTTTACCGAACGGAACACGTCGATTTTCCGGAAATGACC
ATCCCGGAGAGCACCATCCGGATTTCGCGCCTGCCGCTGTCAGACGGACGGTTTGCGCGGCTGGTCCGTGAAGAACAGGA
TGCCGCATAA

Structures

Toxin

• AlphaFold DB: R3JIN1