Detailed information of TA system TA183689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 348777..349527
• Replicon: chromosome
• Accession: NZ_CP065960
• Organism: Mammaliicoccus sciuri strain GDK8D55P

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: JCQ35_RS02020
• Protein ID: WP_101494413.1
• Coordinates: 349420..349527 (+)
• Length: 36 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: JCQ35_RS02015
• Protein ID: WP_025904800.1
• Coordinates: 348777..349376 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JCQ35_RS01990	344458..345219	+	762	WP_198471990.1	acetylglutamate kinase	-
JCQ35_RS01995	345710..346837	+	1128	WP_198471991.1	tRNA epoxyqueuosine(34) reductase QueG	-
JCQ35_RS02000	346841..347314	+	474	WP_025904798.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JCQ35_RS02005	347349..347489	-	141	WP_162841915.1	hypothetical protein	-
JCQ35_RS02010	347576..348727	+	1152	WP_198471992.1	N-acetylglucosamine-6-phosphate deacetylase	-
JCQ35_RS02015	348777..349376	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
JCQ35_RS02020	349420..349527	+	108	WP_101494413.1	hypothetical protein	Toxin
JCQ35_RS02025	349681..351069	+	1389	WP_107577221.1	class II fumarate hydratase	-
JCQ35_RS02030	351159..352685	+	1527	WP_126477940.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4130.43 Da
• Isoelectric Point: 3.7615

>T183689 WP_101494413.1 NZ_CP065960:349420-349527 [Mammaliicoccus sciuri]
MVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 108 bp

>T183689 NZ_CP087155:c10141-9827 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT183689 WP_025904800.1 NZ_CP065960:348777-349376 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT183689 NZ_CP087155:c10407-10129 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6