Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 163373..163912 | Replicon | chromosome |
Accession | NZ_CP065960 | ||
Organism | Mammaliicoccus sciuri strain GDK8D55P |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A8E2VFW5 |
Locus tag | JCQ35_RS00960 | Protein ID | WP_025904511.1 |
Coordinates | 163541..163912 (+) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A657XHG2 |
Locus tag | JCQ35_RS00955 | Protein ID | WP_025904510.1 |
Coordinates | 163373..163540 (+) | Length | 56 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JCQ35_RS00930 | 159256..159735 | + | 480 | WP_159315401.1 | PH domain-containing protein | - |
JCQ35_RS00935 | 159725..161245 | + | 1521 | WP_198471926.1 | PH domain-containing protein | - |
JCQ35_RS00940 | 161235..161699 | + | 465 | WP_159315399.1 | PH domain-containing protein | - |
JCQ35_RS00945 | 161730..162092 | + | 363 | WP_198472315.1 | holo-ACP synthase | - |
JCQ35_RS00950 | 162140..163288 | + | 1149 | WP_159315398.1 | alanine racemase | - |
JCQ35_RS00955 | 163373..163540 | + | 168 | WP_025904510.1 | hypothetical protein | Antitoxin |
JCQ35_RS00960 | 163541..163912 | + | 372 | WP_025904511.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
JCQ35_RS00965 | 164009..165013 | + | 1005 | WP_037589756.1 | PP2C family protein-serine/threonine phosphatase | - |
JCQ35_RS00970 | 165118..165441 | + | 324 | WP_025904513.1 | anti-sigma factor antagonist | - |
JCQ35_RS00975 | 165446..165922 | + | 477 | WP_025904514.1 | anti-sigma B factor RsbW | - |
JCQ35_RS00980 | 165897..166667 | + | 771 | WP_037589755.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13641.78 Da Isoelectric Point: 9.9193
>T183688 WP_025904511.1 NZ_CP065960:163541-163912 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDTLGNT
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDTLGNT
Download Length: 372 bp
>T183688 NZ_CP087153:132137-132286 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 56 a.a. Molecular weight: 6136.65 Da Isoelectric Point: 4.0121
>AT183688 WP_025904510.1 NZ_CP065960:163373-163540 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE
Download Length: 168 bp
>AT183688 NZ_CP087153:c132092-132033 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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