Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 163373..163912 Replicon chromosome
Accession NZ_CP065960
Organism Mammaliicoccus sciuri strain GDK8D55P

Toxin (Protein)


Gene name mazF Uniprot ID A0A8E2VFW5
Locus tag JCQ35_RS00960 Protein ID WP_025904511.1
Coordinates 163541..163912 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag JCQ35_RS00955 Protein ID WP_025904510.1
Coordinates 163373..163540 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCQ35_RS00930 159256..159735 + 480 WP_159315401.1 PH domain-containing protein -
JCQ35_RS00935 159725..161245 + 1521 WP_198471926.1 PH domain-containing protein -
JCQ35_RS00940 161235..161699 + 465 WP_159315399.1 PH domain-containing protein -
JCQ35_RS00945 161730..162092 + 363 WP_198472315.1 holo-ACP synthase -
JCQ35_RS00950 162140..163288 + 1149 WP_159315398.1 alanine racemase -
JCQ35_RS00955 163373..163540 + 168 WP_025904510.1 hypothetical protein Antitoxin
JCQ35_RS00960 163541..163912 + 372 WP_025904511.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JCQ35_RS00965 164009..165013 + 1005 WP_037589756.1 PP2C family protein-serine/threonine phosphatase -
JCQ35_RS00970 165118..165441 + 324 WP_025904513.1 anti-sigma factor antagonist -
JCQ35_RS00975 165446..165922 + 477 WP_025904514.1 anti-sigma B factor RsbW -
JCQ35_RS00980 165897..166667 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13641.78 Da        Isoelectric Point: 9.9193

>T183688 WP_025904511.1 NZ_CP065960:163541-163912 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDTAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T183688 NZ_CP087153:132137-132286 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT183688 WP_025904510.1 NZ_CP065960:163373-163540 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT183688 NZ_CP087153:c132092-132033 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References