Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4911237..4911753 Replicon chromosome
Accession NZ_CP065949
Organism Klebsiella pneumoniae strain KP2509

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag JDE60_RS24420 Protein ID WP_002886902.1
Coordinates 4911237..4911521 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JDE60_RS24425 Protein ID WP_002886901.1
Coordinates 4911511..4911753 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDE60_RS24395 (JDE60_24380) 4906721..4906984 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
JDE60_RS24400 (JDE60_24385) 4907114..4907287 + 174 WP_002886906.1 hypothetical protein -
JDE60_RS24405 (JDE60_24390) 4907290..4908033 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JDE60_RS24410 (JDE60_24395) 4908390..4910528 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
JDE60_RS24415 (JDE60_24400) 4910769..4911233 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JDE60_RS24420 (JDE60_24405) 4911237..4911521 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JDE60_RS24425 (JDE60_24410) 4911511..4911753 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JDE60_RS24430 (JDE60_24415) 4911831..4913741 - 1911 WP_004152270.1 PRD domain-containing protein -
JDE60_RS24435 (JDE60_24420) 4913764..4914918 - 1155 WP_002886900.1 lactonase family protein -
JDE60_RS24440 (JDE60_24425) 4914984..4915724 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T183680 WP_002886902.1 NZ_CP065949:c4911521-4911237 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T183680 NZ_CP065949:c4911521-4911237 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT183680 WP_002886901.1 NZ_CP065949:c4911753-4911511 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT183680 NZ_CP065949:c4911753-4911511 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References