Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5462443..5462948 Replicon chromosome
Accession NZ_CP065948
Organism Pseudomonas aeruginosa strain PAM68

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag JBL37_RS25630 Protein ID WP_003121619.1
Coordinates 5462443..5462724 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag JBL37_RS25635 Protein ID WP_003112628.1
Coordinates 5462721..5462948 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL37_RS25605 (JBL37_25610) 5457694..5459043 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
JBL37_RS25610 (JBL37_25615) 5459092..5459778 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
JBL37_RS25615 (JBL37_25620) 5459879..5460613 + 735 WP_003117208.1 GntR family transcriptional regulator -
JBL37_RS25620 (JBL37_25625) 5460793..5461203 + 411 WP_003101225.1 aegerolysin family protein -
JBL37_RS25625 (JBL37_25630) 5461235..5462143 - 909 WP_003083769.1 LysR family transcriptional regulator -
JBL37_RS25630 (JBL37_25635) 5462443..5462724 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
JBL37_RS25635 (JBL37_25640) 5462721..5462948 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
JBL37_RS25640 (JBL37_25645) 5463124..5463744 - 621 WP_003101226.1 hypothetical protein -
JBL37_RS25645 (JBL37_25650) 5463845..5464345 + 501 WP_003101228.1 LEA type 2 family protein -
JBL37_RS25650 (JBL37_25655) 5464418..5464759 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
JBL37_RS25655 (JBL37_25660) 5464841..5466268 - 1428 WP_003083784.1 GABA permease -
JBL37_RS25660 (JBL37_25665) 5466437..5467930 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T183664 WP_003121619.1 NZ_CP065948:c5462724-5462443 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T183664 NZ_CP087146:c4914200-4913916 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT183664 WP_003112628.1 NZ_CP065948:c5462948-5462721 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT183664 NZ_CP087146:c4914432-4914190 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References