Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1901057..1901562 Replicon chromosome
Accession NZ_CP065947
Organism Pseudomonas aeruginosa strain PAS6

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag JBL36_RS08980 Protein ID WP_003121619.1
Coordinates 1901281..1901562 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag JBL36_RS08975 Protein ID WP_003112628.1
Coordinates 1901057..1901284 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL36_RS08950 (JBL36_08950) 1896075..1897568 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
JBL36_RS08955 (JBL36_08955) 1897737..1899164 + 1428 WP_003083784.1 GABA permease -
JBL36_RS08960 (JBL36_08960) 1899246..1899587 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
JBL36_RS08965 (JBL36_08965) 1899660..1900160 - 501 WP_003101228.1 LEA type 2 family protein -
JBL36_RS08970 (JBL36_08970) 1900261..1900881 + 621 WP_003101226.1 hypothetical protein -
JBL36_RS08975 (JBL36_08975) 1901057..1901284 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
JBL36_RS08980 (JBL36_08980) 1901281..1901562 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
JBL36_RS08985 (JBL36_08985) 1901862..1902770 + 909 WP_003083769.1 LysR family transcriptional regulator -
JBL36_RS08990 (JBL36_08990) 1902802..1903212 - 411 WP_003101225.1 aegerolysin family protein -
JBL36_RS08995 (JBL36_08995) 1903392..1904126 - 735 WP_003117208.1 GntR family transcriptional regulator -
JBL36_RS09000 (JBL36_09000) 1904227..1904913 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
JBL36_RS09005 (JBL36_09005) 1904962..1906311 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T183656 WP_003121619.1 NZ_CP065947:1901281-1901562 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T183656 NZ_CP087146:323794-324162 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT183656 WP_003112628.1 NZ_CP065947:1901057-1901284 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT183656 NZ_CP087146:323576-323797 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References