Detailed information of TA system TA183652

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3980551..3981211
• Replicon: chromosome
• Accession: NZ_CP065946
• Organism: Pectobacterium parmentieri strain WC19161

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8B3EZX7
• Locus tag: JBL47_RS18110
• Protein ID: WP_012822581.1
• Coordinates: 3980551..3980964 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0H3I0G9
• Locus tag: JBL47_RS18115
• Protein ID: WP_012822580.1
• Coordinates: 3980945..3981211 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JBL47_RS18080	3975591..3976409	-	819	WP_025919822.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
JBL47_RS18085	3976427..3977095	-	669	WP_012822586.1	ABC transporter permease	-
JBL47_RS18090	3977088..3978104	-	1017	WP_012822585.1	methionine ABC transporter ATP-binding protein	-
JBL47_RS18095	3978432..3978950	+	519	WP_012822584.1	flavodoxin FldB	-
JBL47_RS18100	3978979..3979302	+	324	WP_012822583.1	hypothetical protein	-
JBL47_RS18105	3979390..3980325	-	936	WP_012822582.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
JBL47_RS18110	3980551..3980964	-	414	WP_012822581.1	protein YgfX	Toxin
JBL47_RS18115	3980945..3981211	-	267	WP_012822580.1	FAD assembly factor SdhE	Antitoxin
JBL47_RS18120	3981439..3982440	+	1002	WP_198481803.1	tRNA-modifying protein YgfZ	-
JBL47_RS18125	3982495..3983142	-	648	WP_012822578.1	hemolysin III family protein	-
JBL47_RS18130	3983553..3984161	+	609	WP_012822577.1	HD domain-containing protein	-
JBL47_RS18135	3984215..3985219	+	1005	WP_012822576.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16259.20 Da
• Isoelectric Point: 10.7923

>T183652 WP_012822581.1 NZ_CP065946:c3980964-3980551 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Nucleotide

• Length: 414 bp

>T183652 NZ_CP087143:c84563-84093 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.99 Da
• Isoelectric Point: 5.1392

>AT183652 WP_012822580.1 NZ_CP065946:c3981211-3980945 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT183652 NZ_CP087143:c85003-84560 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A8B3EZX7

Antitoxin

• AlphaFold DB: A0A0H3I0G9