Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3980551..3981211 Replicon chromosome
Accession NZ_CP065946
Organism Pectobacterium parmentieri strain WC19161

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag JBL47_RS18110 Protein ID WP_012822581.1
Coordinates 3980551..3980964 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag JBL47_RS18115 Protein ID WP_012822580.1
Coordinates 3980945..3981211 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL47_RS18080 3975591..3976409 - 819 WP_025919822.1 MetQ/NlpA family ABC transporter substrate-binding protein -
JBL47_RS18085 3976427..3977095 - 669 WP_012822586.1 ABC transporter permease -
JBL47_RS18090 3977088..3978104 - 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
JBL47_RS18095 3978432..3978950 + 519 WP_012822584.1 flavodoxin FldB -
JBL47_RS18100 3978979..3979302 + 324 WP_012822583.1 hypothetical protein -
JBL47_RS18105 3979390..3980325 - 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
JBL47_RS18110 3980551..3980964 - 414 WP_012822581.1 protein YgfX Toxin
JBL47_RS18115 3980945..3981211 - 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
JBL47_RS18120 3981439..3982440 + 1002 WP_198481803.1 tRNA-modifying protein YgfZ -
JBL47_RS18125 3982495..3983142 - 648 WP_012822578.1 hemolysin III family protein -
JBL47_RS18130 3983553..3984161 + 609 WP_012822577.1 HD domain-containing protein -
JBL47_RS18135 3984215..3985219 + 1005 WP_012822576.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T183652 WP_012822581.1 NZ_CP065946:c3980964-3980551 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T183652 NZ_CP087143:c84563-84093 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT183652 WP_012822580.1 NZ_CP065946:c3981211-3980945 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT183652 NZ_CP087143:c85003-84560 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References