Detailed information of TA system TA183650

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3379493..3380127
• Replicon: chromosome
• Accession: NZ_CP065946
• Organism: Pectobacterium parmentieri strain WC19161

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JBL47_RS15425
• Protein ID: WP_192459492.1
• Coordinates: 3379723..3380127 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JBL47_RS15420
• Protein ID: WP_161545905.1
• Coordinates: 3379493..3379723 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JBL47_RS15380	3374918..3375616	+	699	WP_198481701.1	DeoR family transcriptional regulator	-
JBL47_RS15385	3375798..3376367	+	570	WP_198482522.1	hypothetical protein	-
JBL47_RS15390	3376403..3376876	+	474	WP_198481702.1	hypothetical protein	-
JBL47_RS15395	3376893..3377126	+	234	WP_198481703.1	hypothetical protein	-
JBL47_RS15400	3377211..3377684	+	474	WP_198481704.1	DNA repair protein RadC	-
JBL47_RS15405	3377724..3378059	+	336	WP_198481705.1	type IV toxin-antitoxin system YeeU family antitoxin	-
JBL47_RS15410	3378128..3378448	+	321	WP_198481706.1	TA system toxin CbtA family protein	-
JBL47_RS15415	3378566..3379399	+	834	WP_198481707.1	DUF4942 domain-containing protein	-
JBL47_RS15420	3379493..3379723	+	231	WP_161545905.1	antitoxin	Antitoxin
JBL47_RS15425	3379723..3380127	+	405	WP_192459492.1	tRNA(fMet)-specific endonuclease VapC	Toxin
JBL47_RS15430	3380518..3380962	+	445	Protein_3026	DUF4102 domain-containing protein	-
JBL47_RS15435	3381082..3381486	-	405	WP_198481708.1	hypothetical protein	-
JBL47_RS15440	3381946..3382266	-	321	WP_033071068.1	hypothetical protein	-
JBL47_RS15445	3382643..3383938	-	1296	WP_121264607.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3366218..3390659	24441

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15074.30 Da
• Isoelectric Point: 8.0239

>T183650 WP_192459492.1 NZ_CP065946:3379723-3380127 [Pectobacterium parmentieri]
MLKYLLDTNICIYTIKNKPQEVRDAFYRHYGQFAISSITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQTYGFDAAVHT
GQIRAELAKQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVNR

Nucleotide

• Length: 405 bp

>T183650 NZ_CP087143:19053-19469 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8661.71 Da
• Isoelectric Point: 4.3951

>AT183650 WP_161545905.1 NZ_CP065946:3379493-3379723 [Pectobacterium parmentieri]
VEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIITPAGESWDSWFEQDGVTPDFMITREQPDDQIREDF

Nucleotide

• Length: 231 bp

>AT183650 NZ_CP087143:18826-19056 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA