Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1250373..1250899 Replicon chromosome
Accession NZ_CP065946
Organism Pectobacterium parmentieri strain WC19161

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag JBL47_RS05760 Protein ID WP_198482244.1
Coordinates 1250373..1250678 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag JBL47_RS05765 Protein ID WP_198482245.1
Coordinates 1250681..1250899 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JBL47_RS05730 1245560..1245805 - 246 WP_198482240.1 XRE family transcriptional regulator -
JBL47_RS05735 1245839..1247068 - 1230 WP_198482241.1 tyrosine-type recombinase/integrase -
JBL47_RS05740 1247487..1247780 + 294 WP_038921611.1 DUF1778 domain-containing protein -
JBL47_RS05745 1247777..1248265 + 489 WP_198482242.1 GNAT family N-acetyltransferase -
JBL47_RS05750 1248331..1248486 - 156 Protein_1125 transposase -
JBL47_RS05755 1248536..1250137 - 1602 WP_198482243.1 DUF91 domain-containing protein -
JBL47_RS05760 1250373..1250678 - 306 WP_198482244.1 type II toxin-antitoxin system toxin CcdB Toxin
JBL47_RS05765 1250681..1250899 - 219 WP_198482245.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JBL47_RS05770 1250958..1251701 - 744 WP_198482246.1 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
JBL47_RS05775 1251838..1252014 + 177 WP_198482247.1 hypothetical protein -
JBL47_RS05780 1252487..1252828 - 342 WP_198482248.1 hypothetical protein -
JBL47_RS05785 1252969..1253139 + 171 WP_164669135.1 hypothetical protein -
JBL47_RS05790 1253296..1254558 - 1263 WP_198482249.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1248328..1248486 158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11674.51 Da        Isoelectric Point: 5.6210

>T183647 WP_198482244.1 NZ_CP065946:c1250678-1250373 [Pectobacterium parmentieri]
MQFIVYEYKRSSHYKIFVDVQSDIVDTPKRRMVIPLIESHHLSEKVNKTLFPQIRIDGEDYRLMTTELSSVPVKVIGGEI
AALGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T183647 NZ_CP087142:c4917169-4916885 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8174.14 Da        Isoelectric Point: 7.2038

>AT183647 WP_198482245.1 NZ_CP065946:c1250899-1250681 [Pectobacterium parmentieri]
MKHRVSVTVDKDSYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Download         Length: 219 bp

>AT183647 NZ_CP087142:c4917401-4917159 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References