Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1247487..1248265 | Replicon | chromosome |
| Accession | NZ_CP065946 | ||
| Organism | Pectobacterium parmentieri strain WC19161 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | - |
| Locus tag | JBL47_RS05745 | Protein ID | WP_198482242.1 |
| Coordinates | 1247777..1248265 (+) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | A0A3S0Y1Y3 |
| Locus tag | JBL47_RS05740 | Protein ID | WP_038921611.1 |
| Coordinates | 1247487..1247780 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JBL47_RS05710 | 1242620..1242724 | - | 105 | Protein_1117 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| JBL47_RS05715 | 1242724..1243017 | + | 294 | Protein_1118 | IS3 family transposase | - |
| JBL47_RS05720 | 1243183..1245153 | - | 1971 | WP_121265938.1 | acyltransferase | - |
| JBL47_RS05725 | 1245328..1245560 | - | 233 | Protein_1120 | hypothetical protein | - |
| JBL47_RS05730 | 1245560..1245805 | - | 246 | WP_198482240.1 | XRE family transcriptional regulator | - |
| JBL47_RS05735 | 1245839..1247068 | - | 1230 | WP_198482241.1 | tyrosine-type recombinase/integrase | - |
| JBL47_RS05740 | 1247487..1247780 | + | 294 | WP_038921611.1 | DUF1778 domain-containing protein | Antitoxin |
| JBL47_RS05745 | 1247777..1248265 | + | 489 | WP_198482242.1 | GNAT family N-acetyltransferase | Toxin |
| JBL47_RS05750 | 1248331..1248486 | - | 156 | Protein_1125 | transposase | - |
| JBL47_RS05755 | 1248536..1250137 | - | 1602 | WP_198482243.1 | DUF91 domain-containing protein | - |
| JBL47_RS05760 | 1250373..1250678 | - | 306 | WP_198482244.1 | type II toxin-antitoxin system toxin CcdB | - |
| JBL47_RS05765 | 1250681..1250899 | - | 219 | WP_198482245.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| JBL47_RS05770 | 1250958..1251701 | - | 744 | WP_198482246.1 | molybdopterin-guanine dinucleotide biosynthesis protein MobC | - |
| JBL47_RS05775 | 1251838..1252014 | + | 177 | WP_198482247.1 | hypothetical protein | - |
| JBL47_RS05780 | 1252487..1252828 | - | 342 | WP_198482248.1 | hypothetical protein | - |
| JBL47_RS05785 | 1252969..1253139 | + | 171 | WP_164669135.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1248328..1248486 | 158 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 17506.31 Da Isoelectric Point: 7.8051
>T183646 WP_198482242.1 NZ_CP065946:1247777-1248265 [Pectobacterium parmentieri]
MISAPEPLRAEHLLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDQSLHGHGVGRALVRDAGLRVIQVANTIGIRGILVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SL
MISAPEPLRAEHLLSSFCCGVESMDNWLKQRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PVVVLGRLAVDQSLHGHGVGRALVRDAGLRVIQVANTIGIRGILVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SL
Download Length: 489 bp
>T183646 NZ_CP087142:c4814125-4813592 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10856.44 Da Isoelectric Point: 10.1968
>AT183646 WP_038921611.1 NZ_CP065946:1247487-1247780 [Pectobacterium parmentieri]
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK
MPATNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQKK
Download Length: 294 bp
>AT183646 NZ_CP087142:c4814402-4814136 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|