Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3946321..3946978 Replicon chromosome
Accession NZ_CP065939
Organism Enterobacter hormaechei strain MSB1_8J

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag JDC97_RS19180 Protein ID WP_022649305.1
Coordinates 3946321..3946731 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag JDC97_RS19185 Protein ID WP_003863437.1
Coordinates 3946712..3946978 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JDC97_RS19160 3942319..3944052 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
JDC97_RS19165 3944058..3944771 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JDC97_RS19170 3944800..3945696 - 897 WP_022651809.1 site-specific tyrosine recombinase XerD -
JDC97_RS19175 3945798..3946319 + 522 WP_003863440.1 flavodoxin FldB -
JDC97_RS19180 3946321..3946731 - 411 WP_022649305.1 protein YgfX Toxin
JDC97_RS19185 3946712..3946978 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
JDC97_RS19190 3947273..3948253 + 981 WP_003863435.1 tRNA-modifying protein YgfZ -
JDC97_RS19195 3948339..3948998 - 660 WP_003863433.1 hemolysin III family protein -
JDC97_RS19200 3949265..3949996 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
JDC97_RS19205 3950113..3951546 + 1434 WP_022651811.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T183642 WP_022649305.1 NZ_CP065939:c3946731-3946321 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T183642 NZ_CP087142:875935-876342 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT183642 WP_003863437.1 NZ_CP065939:c3946978-3946712 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT183642 NZ_CP087142:875688-875954 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References