Detailed information of TA system TA183640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3020931..3021542
• Replicon: chromosome
• Accession: NZ_CP065939
• Organism: Enterobacter hormaechei strain MSB1_8J

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: D2TUP9
• Locus tag: JDC97_RS14850
• Protein ID: WP_012906750.1
• Coordinates: 3020931..3021110 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JDC97_RS14855
• Protein ID: WP_047737705.1
• Coordinates: 3021132..3021542 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JDC97_RS14815	3016331..3017047	+	717	WP_003859661.1	ABC transporter ATP-binding protein	-
JDC97_RS14820	3017211..3017681	+	471	WP_003859658.1	hypothetical protein	-
JDC97_RS14825	3017687..3018613	-	927	WP_022651459.1	LysR family transcriptional regulator	-
JDC97_RS14830	3018643..3018966	-	324	WP_003859653.1	hypothetical protein	-
JDC97_RS14840	3019654..3019938	+	285	WP_072060371.1	ash family protein	-
JDC97_RS14845	3019850..3020446	+	597	WP_047737708.1	Rha family transcriptional regulator	-
JDC97_RS14850	3020931..3021110	+	180	WP_012906750.1	type II toxin-antitoxin system HicA family toxin	Toxin
JDC97_RS14855	3021132..3021542	+	411	WP_047737705.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JDC97_RS14860	3021624..3022190	+	567	WP_058691493.1	serine acetyltransferase	-
JDC97_RS14865	3022194..3022616	-	423	WP_063842524.1	tail fiber assembly protein	-
JDC97_RS14870	3023698..3024759	-	1062	Protein_2907	phage tail protein	-
JDC97_RS14875	3024762..3025313	-	552	WP_045345258.1	phage tail protein I	-
JDC97_RS14880	3025306..3026220	-	915	WP_058691495.1	baseplate J/gp47 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliA	3016343..3071365	55022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6644.85 Da
• Isoelectric Point: 10.9132

>T183640 WP_012906750.1 NZ_CP065939:3020931-3021110 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Nucleotide

• Length: 180 bp

>T183640 NZ_CP087142:349765-350112 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14874.84 Da
• Isoelectric Point: 4.3793

>AT183640 WP_047737705.1 NZ_CP065939:3021132-3021542 [Enterobacter hormaechei]
MLYPVAIDKGVSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Nucleotide

• Length: 411 bp

>AT183640 NZ_CP087142:350112-350411 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A7D6XDK4