Detailed information of TA system TA183616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1599404..1600016
• Replicon: chromosome
• Accession: NZ_CP065927
• Organism: Streptococcus pyogenes strain emm9ST603

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JAN99_RS07845
• Protein ID: WP_014635711.1
• Coordinates: 1599681..1600016 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: JAN99_RS07840
• Protein ID: WP_002988079.1
• Coordinates: 1599404..1599691 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JAN99_RS07815	1594596..1595579	-	984	WP_136018823.1	tagatose-bisphosphate aldolase	-
JAN99_RS07820	1595583..1596512	-	930	WP_032464566.1	tagatose-6-phosphate kinase	-
JAN99_RS07825	1596558..1597073	-	516	WP_011285170.1	galactose-6-phosphate isomerase subunit LacB	-
JAN99_RS07830	1597108..1597536	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
JAN99_RS07835	1597981..1598754	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
JAN99_RS07840	1599404..1599691	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
JAN99_RS07845	1599681..1600016	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JAN99_RS07850	1600167..1600637	+	471	Protein_1485	tyrosine-type recombinase/integrase family protein	-
JAN99_RS07855	1600751..1601149	+	399	WP_181879099.1	tyrosine-type recombinase/integrase	-
JAN99_RS07860	1601269..1601661	-	393	WP_002982716.1	30S ribosomal protein S9	-
JAN99_RS07865	1601682..1602128	-	447	WP_002982710.1	50S ribosomal protein L13	-
JAN99_RS07870	1602346..1602552	-	207	WP_111693406.1	helix-turn-helix transcriptional regulator	-
JAN99_RS07875	1602549..1603247	-	699	WP_168641509.1	hypothetical protein	-
JAN99_RS07880	1603383..1604243	-	861	WP_011529009.1	DegV family protein	-
JAN99_RS07885	1604340..1604858	-	519	WP_111693408.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T183616 WP_014635711.1 NZ_CP065927:1599681-1600016 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T183616 NZ_CP087136:1504090-1504266 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT183616 WP_002988079.1 NZ_CP065927:1599404-1599691 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT183616 NZ_CP087136:1504312-1504728 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94