Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1013229..1014472 Replicon chromosome
Accession NZ_CP065927
Organism Streptococcus pyogenes strain emm9ST603

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag JAN99_RS05095 Protein ID WP_111693193.1
Coordinates 1013229..1013996 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag JAN99_RS05100 Protein ID WP_111693192.1
Coordinates 1013996..1014472 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JAN99_RS05070 1009842..1010234 - 393 Protein_939 relaxase/mobilization nuclease domain-containing protein -
JAN99_RS05075 1010221..1010586 - 366 WP_111693196.1 MobC family plasmid mobilization relaxosome protein -
JAN99_RS05080 1010596..1010955 - 360 WP_111693195.1 hypothetical protein -
JAN99_RS05085 1011282..1012424 - 1143 WP_111693194.1 AAA family ATPase -
JAN99_RS05090 1012425..1013213 - 789 WP_029174746.1 hypothetical protein -
JAN99_RS05095 1013229..1013996 - 768 WP_111693193.1 zeta toxin family protein Toxin
JAN99_RS05100 1013996..1014472 - 477 WP_111693192.1 helix-turn-helix domain-containing protein Antitoxin
JAN99_RS05105 1014542..1014829 - 288 WP_111693191.1 hypothetical protein -
JAN99_RS05110 1014874..1015269 - 396 WP_111693190.1 chemotaxis protein -
JAN99_RS05115 1015273..1015494 - 222 WP_111693189.1 hypothetical protein -
JAN99_RS05125 1016823..1016993 - 171 WP_168641549.1 hypothetical protein -
JAN99_RS05130 1016977..1017168 - 192 WP_136116398.1 thrombospondin type 3 repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 955464..1089923 134459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29238.18 Da        Isoelectric Point: 6.3613

>T183615 WP_111693193.1 NZ_CP065927:c1013996-1013229 [Streptococcus pyogenes]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVTPKAILLGRQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRPLHPNYLDLQE
KYGKDSVDYTKGFAEKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKGHHDGIVERLVDNLRELETNKLFDQIQIYQRDRTCVYDSETDEGPAADVLQDCLFGKWSKVEEEML
RDIEEKIANLKVSNE

Download         Length: 768 bp

>T183615 NZ_CP087136:c1408731-1408537 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18162.57 Da        Isoelectric Point: 4.6103

>AT183615 WP_111693192.1 NZ_CP065927:c1014472-1013996 [Streptococcus pyogenes]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQKIAFDDETNPWILMSDDLSDLINTKIYLVQSFDEVERYNGYLDGIERILNLAHHQVVA

Download         Length: 477 bp

>AT183615 NZ_CP087136:1408360-1408538 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References