Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 834668..835192 Replicon chromosome
Accession NZ_CP065926
Organism Staphylococcus pseudintermedius strain SP_9261-1A

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JC283_RS03775 Protein ID WP_014613379.1
Coordinates 834839..835192 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JC283_RS03770 Protein ID WP_014613378.1
Coordinates 834668..834838 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC283_RS03745 830557..831030 + 474 WP_014613373.1 PH domain-containing protein -
JC283_RS03750 831023..832552 + 1530 WP_096533708.1 PH domain-containing protein -
JC283_RS03755 832536..833054 + 519 WP_065354119.1 PH domain-containing protein -
JC283_RS03760 833051..833401 + 351 WP_014613376.1 holo-ACP synthase -
JC283_RS03765 833435..834583 + 1149 WP_014613377.1 alanine racemase -
JC283_RS03770 834668..834838 + 171 WP_014613378.1 hypothetical protein Antitoxin
JC283_RS03775 834839..835192 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JC283_RS03780 835250..836254 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JC283_RS03785 836333..836659 + 327 WP_014613381.1 anti-sigma factor antagonist -
JC283_RS03790 836659..837138 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JC283_RS03795 837113..837883 + 771 WP_198458731.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T183614 WP_014613379.1 NZ_CP065926:834839-835192 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T183614 NZ_CP087136:c1266348-1266241 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT183614 WP_014613378.1 NZ_CP065926:834668-834838 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT183614 NZ_CP087136:1266395-1266461 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References