Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 819601..820122 Replicon chromosome
Accession NZ_CP065926
Organism Staphylococcus pseudintermedius strain SP_9261-1A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JC283_RS03700 Protein ID WP_014613364.1
Coordinates 819901..820122 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JC283_RS03695 Protein ID WP_014613363.1
Coordinates 819601..819888 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC283_RS03670 814862..815665 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JC283_RS03675 815655..816293 + 639 WP_014613359.1 thiamine phosphate synthase -
JC283_RS03680 816382..817248 + 867 WP_014613360.1 membrane protein insertase YidC -
JC283_RS03685 817302..817958 - 657 WP_014613361.1 HD domain-containing protein -
JC283_RS03690 817979..819469 - 1491 WP_014613362.1 cardiolipin synthase -
JC283_RS03695 819601..819888 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JC283_RS03700 819901..820122 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JC283_RS03705 820126..820332 + 207 WP_014613365.1 cation transporter -
JC283_RS03710 820433..822613 + 2181 WP_015729432.1 heavy metal translocating P-type ATPase -
JC283_RS03715 822699..822845 + 147 WP_014613367.1 hypothetical protein -
JC283_RS03720 823964..824692 + 729 WP_037542547.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183613 WP_014613364.1 NZ_CP065926:819901-820122 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183613 NZ_CP087136:c1265813-1265706 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183613 WP_014613363.1 NZ_CP065926:819601-819888 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183613 NZ_CP087136:1265860-1265926 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References