183609

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 742573..743094 Replicon chromosome
Accession NZ_CP065925
Organism Staphylococcus pseudintermedius strain SP_11304-1A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JC282_RS03315 Protein ID WP_014613364.1
Coordinates 742873..743094 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JC282_RS03310 Protein ID WP_014613363.1
Coordinates 742573..742860 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC282_RS03285 737834..738637 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JC282_RS03290 738627..739265 + 639 WP_014613359.1 thiamine phosphate synthase -
JC282_RS03295 739354..740220 + 867 WP_014613360.1 membrane protein insertase YidC -
JC282_RS03300 740274..740930 - 657 WP_130922129.1 HD domain-containing protein -
JC282_RS03305 740951..742441 - 1491 WP_014613362.1 cardiolipin synthase -
JC282_RS03310 742573..742860 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JC282_RS03315 742873..743094 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JC282_RS03320 743098..743304 + 207 WP_198455108.1 cation transporter -
JC282_RS03325 743405..745585 + 2181 WP_014613366.1 heavy metal translocating P-type ATPase -
JC282_RS03330 745671..745817 + 147 WP_014613367.1 hypothetical protein -
JC282_RS03335 746935..747663 + 729 WP_198455109.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183609 WP_014613364.1 NZ_CP065925:742873-743094 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183609 NZ_CP087136:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183609 WP_014613363.1 NZ_CP065925:742573-742860 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183609 NZ_CP087136:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References