183606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 847620..848141 Replicon chromosome
Accession NZ_CP065924
Organism Staphylococcus pseudintermedius strain SP_11304-2A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JC285_RS03790 Protein ID WP_014613364.1
Coordinates 847920..848141 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JC285_RS03785 Protein ID WP_014613363.1
Coordinates 847620..847907 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC285_RS03760 842881..843684 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JC285_RS03765 843674..844312 + 639 WP_099997350.1 thiamine phosphate synthase -
JC285_RS03770 844401..845267 + 867 WP_014613360.1 membrane protein insertase YidC -
JC285_RS03775 845321..845977 - 657 WP_070407666.1 HD domain-containing protein -
JC285_RS03780 845998..847488 - 1491 WP_014613362.1 cardiolipin synthase -
JC285_RS03785 847620..847907 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JC285_RS03790 847920..848141 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JC285_RS03795 848145..848351 + 207 WP_014613365.1 cation transporter -
JC285_RS03800 848452..850632 + 2181 WP_099997349.1 heavy metal translocating P-type ATPase -
JC285_RS03805 850718..850864 + 147 WP_014613367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183606 WP_014613364.1 NZ_CP065924:847920-848141 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183606 NZ_CP087132:2868707-2868886 [Flavobacterium sp. F-29]
ATGTACTTTATTGAAAAGACGACGGAATTTGATAAGTGGTTTAAGAAATTGAATGACTTTAGAGCAAAAGCAAAAATTTT
GTTTCGACTTCAAAAGTTAGAAAAGGACGAACACTTTGGAGATTGCGAACCTGTTGGAGATGGAATTAGAGAACTAAAAA
TCAACTACGCAAAAGGTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183606 WP_014613363.1 NZ_CP065924:847620-847907 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183606 NZ_CP087132:2869010-2869294 [Flavobacterium sp. F-29]
ATGGAAACGTCAAAATTTGATATTGCAGATTACTTGGACAGCAACGAAATGATTGCTGAATATCTAAATACCGTTTTGGA
AGAAGGCAATGATGCTGAAATTGTTACTGCAATTGGACATATTGCAAAAGCAATTGGTATGACCAAAATTGCAGAAGAAA
CTAGAATGAGCAGACCAAGTTTGTACAAAGCATTGTCGGAAGGATCCAAACCACAATTTTCAACGATAATGAAAGTTTTG
AAAGCAATTGGAGGACAAATACATATAAATCCATTAACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References