183604

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 823877..824401 Replicon chromosome
Accession NZ_CP065921
Organism Staphylococcus pseudintermedius strain SP_11304-3A

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JC286_RS03640 Protein ID WP_014613379.1
Coordinates 824048..824401 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JC286_RS03635 Protein ID WP_014613378.1
Coordinates 823877..824047 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC286_RS03610 819766..820239 + 474 WP_014613373.1 PH domain-containing protein -
JC286_RS03615 820232..821761 + 1530 WP_014613374.1 PH domain-containing protein -
JC286_RS03620 821745..822263 + 519 WP_014613375.1 PH domain-containing protein -
JC286_RS03625 822260..822610 + 351 WP_014613376.1 holo-ACP synthase -
JC286_RS03630 822644..823792 + 1149 WP_014613377.1 alanine racemase -
JC286_RS03635 823877..824047 + 171 WP_014613378.1 hypothetical protein Antitoxin
JC286_RS03640 824048..824401 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JC286_RS03645 824459..825463 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JC286_RS03650 825542..825868 + 327 WP_014613381.1 anti-sigma factor antagonist -
JC286_RS03655 825868..826347 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JC286_RS03660 826322..827092 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T183604 WP_014613379.1 NZ_CP065921:824048-824401 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T183604 NZ_CP087124:776920-777054 [Sulfurovum sp. HSL1-3]
ATGATCTATCTTTATCTGACAGATAAAAGTCATATTCATCTCTTGACGATCTATGCAAAAAACGAGATGGAAGCGCTTAC
TCCAAGTCAAAAGAAGGTACTCAAAGCGATTACAGAGGAGATCAAAAATGGGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT183604 WP_014613378.1 NZ_CP065921:823877-824047 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT183604 NZ_CP087124:777047-777361 [Sulfurovum sp. HSL1-3]
ATGGGTAAAAGAGATTTGTTTGCAGAGTTGAAGCAGGGGCTTGATGATGCAAGAGCATATGAAGAGGCTAAGCTGACGCT
CAGGACAACGGAAGTGACGCCCAAGGAGCGTAAGGTCCTTACTCCGGAAGAGATACGGGGCATCAGGGAAAAATACCGTA
TGAGTCGGGCGGTATTTGCCAATTTTTTGCATATCTCCACCCGTACGCTTGAGAAGTGGGAGCTTGGGACCAGCAAGCCA
AACGAACAGGCTGTTACGCTGCTTGCATTGACAGATATGTACCCGGATATGTTTGAGCGCCTGGAGAGGGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References