183601

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 805550..806074 Replicon chromosome
Accession NZ_CP065920
Organism Staphylococcus pseudintermedius strain SP_11306-1A

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JC281_RS03560 Protein ID WP_014613379.1
Coordinates 805721..806074 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JC281_RS03555 Protein ID WP_014613378.1
Coordinates 805550..805720 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC281_RS03530 801439..801912 + 474 WP_014613373.1 PH domain-containing protein -
JC281_RS03535 801905..803434 + 1530 WP_110178650.1 PH domain-containing protein -
JC281_RS03540 803418..803936 + 519 WP_014613375.1 PH domain-containing protein -
JC281_RS03545 803933..804283 + 351 WP_110178649.1 holo-ACP synthase -
JC281_RS03550 804317..805465 + 1149 WP_065354670.1 alanine racemase -
JC281_RS03555 805550..805720 + 171 WP_014613378.1 hypothetical protein Antitoxin
JC281_RS03560 805721..806074 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JC281_RS03565 806132..807136 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JC281_RS03570 807215..807541 + 327 WP_014613381.1 anti-sigma factor antagonist -
JC281_RS03575 807541..808020 + 480 WP_180932480.1 anti-sigma B factor RsbW -
JC281_RS03580 807995..808765 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T183601 WP_014613379.1 NZ_CP065920:805721-806074 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T183601 NZ_CP087123:5473099-5473542 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT183601 WP_014613378.1 NZ_CP065920:805550-805720 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT183601 NZ_CP087123:5472872-5473102 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References