183600

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 790483..791004 Replicon chromosome
Accession NZ_CP065920
Organism Staphylococcus pseudintermedius strain SP_11306-1A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JC281_RS03485 Protein ID WP_014613364.1
Coordinates 790783..791004 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JC281_RS03480 Protein ID WP_014613363.1
Coordinates 790483..790770 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC281_RS03455 785744..786547 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JC281_RS03460 786537..787175 + 639 WP_014613359.1 thiamine phosphate synthase -
JC281_RS03465 787264..788130 + 867 WP_014613360.1 membrane protein insertase YidC -
JC281_RS03470 788184..788840 - 657 WP_014613361.1 HD domain-containing protein -
JC281_RS03475 788861..790351 - 1491 WP_014613362.1 cardiolipin synthase -
JC281_RS03480 790483..790770 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JC281_RS03485 790783..791004 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JC281_RS03490 791008..791214 + 207 WP_014613365.1 cation transporter -
JC281_RS03495 791315..793495 + 2181 WP_101485410.1 heavy metal translocating P-type ATPase -
JC281_RS03500 793581..793727 + 147 WP_014613367.1 hypothetical protein -
JC281_RS03505 794846..795574 + 729 WP_110178651.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183600 WP_014613364.1 NZ_CP065920:790783-791004 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183600 NZ_CP087123:c5386495-5386112 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183600 WP_014613363.1 NZ_CP065920:790483-790770 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183600 NZ_CP087123:c5386737-5386495 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References