Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3537679..3538351 Replicon chromosome
Accession NZ_CP065918
Organism Yersinia pestis EV NIIEG

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag AH66_RS15930 Protein ID WP_002215144.1
Coordinates 3537926..3538351 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag AH66_RS15925 Protein ID WP_002209939.1
Coordinates 3537679..3537945 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH66_RS15905 3533536..3534639 + 1104 WP_002209943.1 hypothetical protein -
AH66_RS15910 3534841..3535542 + 702 WP_002209942.1 hemolysin III family protein -
AH66_RS15915 3535800..3536297 + 498 WP_002209941.1 DUF2165 family protein -
AH66_RS15920 3536370..3537362 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
AH66_RS15925 3537679..3537945 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
AH66_RS15930 3537926..3538351 + 426 WP_002215144.1 protein YgfX Toxin
AH66_RS15935 3538351..3539049 + 699 WP_002209937.1 two-component system response regulator CreB -
AH66_RS15940 3539074..3540492 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
AH66_RS15945 3540613..3542025 + 1413 WP_025471084.1 cell envelope integrity protein CreD -
AH66_RS15950 3542159..3542677 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T183594 WP_002215144.1 NZ_CP065918:3537926-3538351 [Yersinia pestis EV NIIEG]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T183594 NZ_CP087123:797924-798334 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT183594 WP_002209939.1 NZ_CP065918:3537679-3537945 [Yersinia pestis EV NIIEG]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT183594 NZ_CP087123:797677-797943 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References