Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1905794..1906440 Replicon chromosome
Accession NZ_CP065918
Organism Yersinia pestis EV NIIEG

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag AH66_RS08375 Protein ID WP_002214976.1
Coordinates 1906258..1906440 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag AH66_RS08370 Protein ID WP_002211129.1
Coordinates 1905794..1906213 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH66_RS08350 1900865..1901860 + 996 WP_002211125.1 substrate-binding domain-containing protein -
AH66_RS08355 1901926..1903503 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
AH66_RS08360 1903506..1904528 + 1023 WP_002214974.1 ABC transporter permease -
AH66_RS08365 1904577..1905536 + 960 WP_002211128.1 sugar kinase -
AH66_RS08370 1905794..1906213 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AH66_RS08375 1906258..1906440 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
AH66_RS08380 1906647..1907429 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
AH66_RS08385 1907432..1907701 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
AH66_RS08390 1907807..1908547 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
AH66_RS08395 1908628..1909164 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
AH66_RS08400 1909164..1909580 - 417 WP_002211134.1 flagellar motor switch protein FliN -
AH66_RS08405 1909577..1910578 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
AH66_RS08410 1910584..1911054 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T183592 WP_002214976.1 NZ_CP065918:c1906440-1906258 [Yersinia pestis EV NIIEG]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T183592 NZ_CP087123:327908-328276 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT183592 WP_002211129.1 NZ_CP065918:c1906213-1905794 [Yersinia pestis EV NIIEG]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT183592 NZ_CP087123:327690-327911 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References