Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1122126..1122746 Replicon chromosome
Accession NZ_CP065918
Organism Yersinia pestis EV NIIEG

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag AH66_RS04935 Protein ID WP_002208622.1
Coordinates 1122126..1122329 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag AH66_RS04940 Protein ID WP_002218472.1
Coordinates 1122378..1122746 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH66_RS04905 1117148..1117486 + 339 WP_002208627.1 P-II family nitrogen regulator -
AH66_RS04910 1117526..1118815 + 1290 WP_002228344.1 ammonium transporter AmtB -
AH66_RS04915 1119075..1119935 - 861 WP_002208625.1 acyl-CoA thioesterase II -
AH66_RS04920 1120192..1120713 + 522 WP_002208624.1 lipoprotein -
AH66_RS04925 1120849..1121238 - 390 WP_002208623.1 MGMT family protein -
AH66_RS04935 1122126..1122329 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
AH66_RS04940 1122378..1122746 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
AH66_RS04945 1122905..1123258 - 354 WP_002208619.1 hypothetical protein -
AH66_RS04950 1124132..1124275 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
AH66_RS04955 1124291..1124551 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T183583 WP_002208622.1 NZ_CP065918:c1122329-1122126 [Yersinia pestis EV NIIEG]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T183583 NZ_CP087122:3912344-3912562 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT183583 WP_002218472.1 NZ_CP065918:c1122746-1122378 [Yersinia pestis EV NIIEG]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT183583 NZ_CP087122:3911943-3912317 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTTTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References