Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1388..1920 Replicon plasmid pCP157_14
Accession NZ_CP065906
Organism Paracoccus marcusii strain CP157

Toxin (Protein)


Gene name parE Uniprot ID A0A139WPW9
Locus tag CP157_RS19970 Protein ID WP_066613605.1
Coordinates 1633..1920 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A139WPW5
Locus tag CP157_RS19965 Protein ID WP_066613603.1
Coordinates 1388..1636 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP157_RS19955 (CP157_04008) 79..576 + 498 WP_217847086.1 helix-turn-helix domain-containing protein -
CP157_RS19960 579..827 - 249 WP_217847087.1 hypothetical protein -
CP157_RS19965 (CP157_04010) 1388..1636 + 249 WP_066613603.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CP157_RS19970 (CP157_04011) 1633..1920 + 288 WP_066613605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP157_RS19975 (CP157_04012) 2010..2231 + 222 WP_148663113.1 hypothetical protein -
CP157_RS19980 (CP157_04013) 2292..2483 + 192 WP_217847088.1 hypothetical protein -
CP157_RS19985 (CP157_04014) 2674..2970 - 297 WP_217847089.1 hypothetical protein -
CP157_RS19990 (CP157_04015) 3416..4663 + 1248 WP_217847090.1 hypothetical protein -
CP157_RS19995 (CP157_04016) 4787..5542 + 756 WP_217847083.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8099 8099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10922.21 Da        Isoelectric Point: 6.8691

>T183582 WP_066613605.1 NZ_CP065906:1633-1920 [Paracoccus marcusii]
MKPLAFSPAAEADIDGIWDYSAQTWGPDQADRYTDEIRDACLALAHDRKQGRPVDVRPGYLRLSTGSHVIYYRNRGDRLD
VIRVLHNRMDADRHL

Download         Length: 288 bp

>T183582 NZ_CP087122:c3789277-3788960 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8911.93 Da        Isoelectric Point: 5.6939

>AT183582 WP_066613603.1 NZ_CP065906:1388-1636 [Paracoccus marcusii]
MPRTTSVSLGEHFTGFISAQVDAGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEQSGEPRPFDFDSFKARKRAEFE
AG

Download         Length: 249 bp

>AT183582 NZ_CP087122:c3788967-3788680 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGGGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A139WPW9

Antitoxin

Source ID Structure
AlphaFold DB A0A139WPW5

References