Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 1388..1920 | Replicon | plasmid pCP157_14 |
Accession | NZ_CP065906 | ||
Organism | Paracoccus marcusii strain CP157 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A139WPW9 |
Locus tag | CP157_RS19970 | Protein ID | WP_066613605.1 |
Coordinates | 1633..1920 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A139WPW5 |
Locus tag | CP157_RS19965 | Protein ID | WP_066613603.1 |
Coordinates | 1388..1636 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CP157_RS19955 (CP157_04008) | 79..576 | + | 498 | WP_217847086.1 | helix-turn-helix domain-containing protein | - |
CP157_RS19960 | 579..827 | - | 249 | WP_217847087.1 | hypothetical protein | - |
CP157_RS19965 (CP157_04010) | 1388..1636 | + | 249 | WP_066613603.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
CP157_RS19970 (CP157_04011) | 1633..1920 | + | 288 | WP_066613605.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
CP157_RS19975 (CP157_04012) | 2010..2231 | + | 222 | WP_148663113.1 | hypothetical protein | - |
CP157_RS19980 (CP157_04013) | 2292..2483 | + | 192 | WP_217847088.1 | hypothetical protein | - |
CP157_RS19985 (CP157_04014) | 2674..2970 | - | 297 | WP_217847089.1 | hypothetical protein | - |
CP157_RS19990 (CP157_04015) | 3416..4663 | + | 1248 | WP_217847090.1 | hypothetical protein | - |
CP157_RS19995 (CP157_04016) | 4787..5542 | + | 756 | WP_217847083.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..8099 | 8099 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10922.21 Da Isoelectric Point: 6.8691
>T183582 WP_066613605.1 NZ_CP065906:1633-1920 [Paracoccus marcusii]
MKPLAFSPAAEADIDGIWDYSAQTWGPDQADRYTDEIRDACLALAHDRKQGRPVDVRPGYLRLSTGSHVIYYRNRGDRLD
VIRVLHNRMDADRHL
MKPLAFSPAAEADIDGIWDYSAQTWGPDQADRYTDEIRDACLALAHDRKQGRPVDVRPGYLRLSTGSHVIYYRNRGDRLD
VIRVLHNRMDADRHL
Download Length: 288 bp
>T183582 NZ_CP087122:c3789277-3788960 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8911.93 Da Isoelectric Point: 5.6939
>AT183582 WP_066613603.1 NZ_CP065906:1388-1636 [Paracoccus marcusii]
MPRTTSVSLGEHFTGFISAQVDAGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEQSGEPRPFDFDSFKARKRAEFE
AG
MPRTTSVSLGEHFTGFISAQVDAGRYGSASDVVRAGLRLLEEHEAKVKALQDALIAGEQSGEPRPFDFDSFKARKRAEFE
AG
Download Length: 249 bp
>AT183582 NZ_CP087122:c3788967-3788680 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGGGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGGGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A139WPW9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A139WPW5 |