Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 36429..36990 Replicon plasmid pCP157_04
Accession NZ_CP065896
Organism Paracoccus marcusii strain CP157

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CP157_RS18505 Protein ID WP_217846893.1
Coordinates 36429..36704 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CP157_RS18510 Protein ID WP_217846894.1
Coordinates 36697..36990 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP157_RS18470 (CP157_03731) 33055..33243 + 189 WP_127899939.1 heavy-metal-associated domain-containing protein -
CP157_RS18475 (CP157_03732) 33446..33901 - 456 WP_245008565.1 DUF411 domain-containing protein -
CP157_RS18480 (CP157_03733) 33898..34359 - 462 WP_217846889.1 Cu(I)-responsive transcriptional regulator -
CP157_RS18485 (CP157_03734) 34509..35093 - 585 WP_245008566.1 DUF305 domain-containing protein -
CP157_RS18490 (CP157_03735) 35090..35212 - 123 WP_245008567.1 copper-binding protein -
CP157_RS18495 35241..35573 - 333 WP_217846891.1 cytochrome c -
CP157_RS20520 (CP157_03736) 35585..35713 - 129 WP_276523133.1 hypothetical protein -
CP157_RS18500 35952..36293 - 342 WP_217846892.1 hypothetical protein -
CP157_RS18505 36429..36704 - 276 WP_217846893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP157_RS18510 (CP157_03737) 36697..36990 - 294 WP_217846894.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CP157_RS18515 (CP157_03738) 37500..38936 + 1437 WP_217846895.1 IS1182 family transposase -
CP157_RS18520 (CP157_03739) 39297..40469 + 1173 WP_217846214.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..96460 96460
- flank IS/Tn - - 39297..40469 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10171.85 Da        Isoelectric Point: 5.6479

>T183581 WP_217846893.1 NZ_CP065896:c36704-36429 [Paracoccus marcusii]
VPELEWKAFAVADLMAIVDYISDDNPDAALALMEEIQGKVAQLPMHPKRCRSGRVQGTRELVVRPNYIVIYAETPSAVTV
LRVLHAAQMWP

Download         Length: 276 bp

>T183581 NZ_CP087122:c2578311-2576989 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGATAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCTGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGTGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGGCATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10386.82 Da        Isoelectric Point: 7.4036

>AT183581 WP_217846894.1 NZ_CP065896:c36990-36697 [Paracoccus marcusii]
MPTHTSMLHVRVDDHLKAQASSALAGVGLTLSDAVRILLTRVAAEGGLPAGLTANPESYDSWFRAKVQEALTDTRPSVPH
DQVMRDVRALIDGKRGA

Download         Length: 294 bp

>AT183581 NZ_CP087122:c2578577-2578311 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References