Detailed information of TA system TA183580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParE-CopA/ParE-RHH
• Location: 110490..111055
• Replicon: plasmid pCP157_03
• Accession: NZ_CP065895
• Organism: Paracoccus marcusii strain CP157

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0D6TCU3
• Locus tag: CP157_RS18050
• Protein ID: WP_045999878.1
• Coordinates: 110762..111055 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: copA
• Uniprot ID: -
• Locus tag: CP157_RS18045
• Protein ID: WP_084693731.1
• Coordinates: 110490..110774 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP157_RS18005 (CP157_03644)	105924..106421	-	498	WP_194886534.1	ferritin-like domain-containing protein	-
CP157_RS18010 (CP157_03645)	106482..106997	-	516	WP_194886535.1	ferritin-like domain-containing protein	-
CP157_RS18015 (CP157_03646)	107313..107759	-	447	WP_194886536.1	DUF421 domain-containing protein	-
CP157_RS18020 (CP157_03647)	107769..108278	-	510	WP_217846752.1	hypothetical protein	-
CP157_RS18025 (CP157_03648)	108605..109228	+	624	WP_045999883.1	hypothetical protein	-
CP157_RS18030 (CP157_03649)	109352..109549	+	198	WP_157020436.1	hypothetical protein	-
CP157_RS18035 (CP157_03650)	109635..109823	+	189	WP_139599605.1	hypothetical protein	-
CP157_RS18040 (CP157_03651)	109894..110187	+	294	WP_045999880.1	HU family DNA-binding protein	-
CP157_RS18045 (CP157_03652)	110490..110774	+	285	WP_084693731.1	ribbon-helix-helix protein, CopG family	Antitoxin
CP157_RS18050 (CP157_03653)	110762..111055	+	294	WP_045999878.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP157_RS18055 (CP157_03654)	111855..112661	-	807	WP_194886539.1	inositol monophosphatase family protein	-
CP157_RS18060	112658..113536	-	879	WP_276523130.1	PfkB family carbohydrate kinase	-
CP157_RS18065	114250..115367	-	1118	Protein_123	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	ugd	1..158154	158154
	-	flank	IS/Tn	-	-	114250..114675	425

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-44)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10817.52 Da
• Isoelectric Point: 10.1858

>T183580 WP_045999878.1 NZ_CP065895:110762-111055 [Paracoccus marcusii]
MPQLIWTPKSLQGVQRCYRFLASKNPDAASRAVRAIREGMQIVAAQPGVGRPADKMAPEFREWLIAFGDSGYTVLYQVDG
KQAVVLAIRHQREAGYL

Nucleotide

• Length: 294 bp

>T183580 NZ_CP065895:110762-111055 [Paracoccus marcusii]
ATGCCACAGCTGATCTGGACGCCGAAATCGCTGCAGGGCGTCCAGCGGTGCTATCGGTTTCTGGCTTCCAAAAACCCGGA
TGCCGCGTCCCGCGCAGTGCGGGCCATCCGGGAGGGCATGCAGATCGTAGCCGCGCAGCCGGGCGTAGGGCGCCCGGCCG
ACAAGATGGCCCCGGAGTTCCGGGAGTGGCTGATCGCGTTTGGGGACAGCGGCTATACGGTCCTCTATCAGGTGGACGGC
AAACAGGCCGTCGTTCTGGCGATCAGGCATCAGCGTGAGGCAGGATACTTATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10691.96 Da
• Isoelectric Point: 5.8964

>AT183580 WP_084693731.1 NZ_CP065895:110490-110774 [Paracoccus marcusii]
MAAVHPVAVKLDAEVHARMRELAKAQNRTPHYLMREAIAQYVEREEKREAFRQEALTAWASYQTTGLHVSHAEADNWLAQ
LEAGQDVEPPECHS

Nucleotide

• Length: 285 bp

>AT183580 NZ_CP065895:110490-110774 [Paracoccus marcusii]
ATGGCTGCCGTTCACCCTGTTGCCGTAAAGCTGGATGCCGAGGTTCATGCCCGGATGCGGGAACTTGCCAAAGCACAAAA
CCGTACCCCGCATTACCTGATGCGGGAGGCCATCGCTCAGTATGTTGAACGCGAGGAAAAGCGTGAGGCGTTTCGGCAGG
AGGCGCTGACGGCATGGGCGTCCTATCAGACCACTGGCCTGCATGTGTCTCATGCCGAGGCGGACAACTGGTTGGCTCAG
CTCGAAGCTGGTCAGGATGTAGAACCGCCTGAATGCCACAGCTGA

Structures

Toxin

• AlphaFold DB: A0A0D6TCU3