Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4650252..4650892 Replicon chromosome
Accession NZ_CP065867
Organism Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I9X29_RS21620 Protein ID WP_003134109.1
Coordinates 4650252..4650662 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I9X29_RS21625 Protein ID WP_031634724.1
Coordinates 4650662..4650892 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X29_RS21580 4646378..4646575 + 198 WP_019396765.1 hypothetical protein -
I9X29_RS21585 4646732..4647460 + 729 WP_004352842.1 TIGR03761 family integrating conjugative element protein -
I9X29_RS21590 4647466..4648014 + 549 WP_004352841.1 DUF3158 family protein -
I9X29_RS21595 4648061..4648900 + 840 WP_003105750.1 Rha family transcriptional regulator -
I9X29_RS21600 4648930..4649418 + 489 WP_004352840.1 single-stranded DNA-binding protein -
I9X29_RS21605 4649574..4649741 + 168 WP_128729268.1 CrpP family protein -
I9X29_RS21610 4649807..4650025 - 219 WP_023083218.1 hypothetical protein -
I9X29_RS21615 4650039..4650236 - 198 WP_023083219.1 hypothetical protein -
I9X29_RS21620 4650252..4650662 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
I9X29_RS21625 4650662..4650892 - 231 WP_031634724.1 antitoxin Antitoxin
I9X29_RS21630 4651148..4653067 + 1920 WP_004352838.1 type I DNA topoisomerase -
I9X29_RS21635 4653375..4653584 + 210 WP_003105733.1 cold-shock protein -
I9X29_RS21640 4653805..4655694 + 1890 WP_003105732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA / katA 4632181..4763592 131411


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T183577 WP_003134109.1 NZ_CP065867:c4650662-4650252 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T183577 NZ_CP087122:349272-349619 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTATGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT183577 WP_031634724.1 NZ_CP065867:c4650892-4650662 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT183577 NZ_CP087122:349619-349918 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References