Detailed information of TA system TA183575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3565370..3566591
• Replicon: chromosome
• Accession: NZ_CP065867
• Organism: Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: I9X29_RS16310
• Protein ID: WP_003102740.1
• Coordinates: 3566013..3566591 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I9X29_RS16305
• Protein ID: WP_003088112.1
• Coordinates: 3565370..3565924 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9X29_RS16280	3560938..3561489	+	552	WP_198340685.1	XRE family transcriptional regulator	-
I9X29_RS16285	3561486..3561884	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
I9X29_RS16290	3561897..3562220	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
I9X29_RS16295	3562551..3563012	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
I9X29_RS16300	3563017..3565212	+	2196	WP_031638145.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
I9X29_RS16305	3565370..3565924	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
I9X29_RS16310	3566013..3566591	+	579	WP_003102740.1	HD domain-containing protein	Toxin
I9X29_RS16315	3566588..3567217	-	630	WP_057385837.1	LysE family translocator	-
I9X29_RS16320	3567415..3568602	-	1188	WP_003139884.1	HlyD family efflux transporter periplasmic adaptor subunit	-
I9X29_RS16325	3568592..3570763	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T183575 WP_003102740.1 NZ_CP065867:3566013-3566591 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T183575 NZ_CP087114:c2192748-2192422 [Bartonella machadoae]
ATGATGCGTGGATCTCTCGTAACAATAGCGATGCAGGGTGATTTTGGTAAACCAAGACCTGCATTAATAATTCAAGCCAA
TCAATTCAGCGAACATACAAGCGTAACAGTTTTACCAATTACAAGTACACTTATTGCAGCACCATTACTTCGCATTACTA
TTCAACCAGATGCCAAAAACGGTTTACAAAAGCTTTCACAAGTGATGATTGATAAGATCATGACGGTAGGATGCGAAAAG
GTTATTCTAGCTTTCGGTTCTATGCATGCAGATAAAATGGTAGAAATTGAACGCTGTTTGGCTGTGTTTTTAGGAATAGT
AAAATGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT183575 WP_003088112.1 NZ_CP065867:3565370-3565924 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT183575 NZ_CP087114:c2192969-2192745 [Bartonella machadoae]
ATGGCTACAATGCACGTTAATGAACGCGTTCAAAAACATCGCAACGCACAAAGGAAAGCAGGATTGCGCTTGATGCAAAT
TTGGGTACCAGATACACGTCAACCAAACTTTGCAGAAGAGTGCCGTCGTCAGTGTCGCTTGGTAGCAAAAATGGATAAAA
CAGATACATCTATGCAATTATTTATGGATCAATCTGTAGTGGATGTTGATGGCTGGACAGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07