Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1902318..1903826 Replicon chromosome
Accession NZ_CP065867
Organism Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag I9X29_RS08925 Protein ID WP_003119682.1
Coordinates 1902318..1902905 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag I9X29_RS08930 Protein ID WP_003091607.1
Coordinates 1902972..1903826 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X29_RS08920 1898573..1902052 - 3480 WP_019371586.1 hybrid sensor histidine kinase/response regulator -
I9X29_RS08925 1902318..1902905 + 588 WP_003119682.1 GNAT family N-acetyltransferase Toxin
I9X29_RS08930 1902972..1903826 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
I9X29_RS08935 1903923..1906088 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
I9X29_RS08940 1906263..1908137 + 1875 WP_198341263.1 MFS transporter -
I9X29_RS08945 1908198..1908407 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T183574 WP_003119682.1 NZ_CP065867:1902318-1902905 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T183574 NZ_CP087114:c2110548-2109796 [Bartonella machadoae]
GTGGTGAAGTATGAGAATAAAAATGATCCTTATACTGATCCTGAAACTGGTGTGATGTATAATCGGCTTGGTATTAAAGA
CCAAGCCACTCTAAGGAGTGTGGAATCTTCTTTTGCTTATATAAGGTCTTATGAACTTGATAGCACTCCTATTAAGGGTA
AGTTTGATCTCAATCACATGAAAGAGATTCATAAAAAGCTGTTTGGTGACGTCTATGAATGGGCAGGAGAAATCCGTTCA
ATAGATATTAGCAAAGGGGGAAGTCTGTTTGCTTATCATCATAAGATTGAAAGTTATGCACCGAAGATTACACAGCAGCT
TGCCAAAGAACAATATCTAGGGGGGCTTGATGCGGATGAATTCAGCCAGAGAGCTGGATATTATATGGGTGAAATAAATG
CGTTGCATCCGTTTCGAGAGGGGAATGGACGTACTCAGCGTGAATTTATTGGTCAACTTGCTCGTGAAGCTGGTTATAAT
ATTCATTGGGAGGGGGTTAAACGAGAGGAAATGACAAAAGCCTCCATTGAGGCACTTTATGGCAGTTCTGAATTACTGTC
TGGGCTTATTCGTAAGAGCCTTACTGAATTTACAAAAAATAAAAATGTTGACGTTTCGAAAGGTCTAGGAGAGAAAATTT
CCTCTTACATTGAGACGAATAAAGAATTATCGCAGAAACAAAAAGAAAAGATTGAAACGCTTTTGGATAAAGTAAAGCCA
AATGTTGGCAATCTTCAAAAAAAAAGAACCTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT183574 WP_003091607.1 NZ_CP065867:1902972-1903826 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT183574 NZ_CP087114:c2110723-2110535 [Bartonella machadoae]
ATGTTGAGTGAAGAGGAAATTAAGCAACGTCGCTTTGCTGCTAAAAATGCATTAGCAAATCAACGTTTAGAGGGTTTGGA
GCCAGATCCACAGGTCGTTGCACAGATGGAACGGGTTATTATTGGAGAACTTGAAACAAGTGATGTAATCAAAGATCTTA
TGGAGCGTGTAAAACGTGGTGAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References