Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142535..143040 Replicon chromosome
Accession NZ_CP065867
Organism Pseudomonas aeruginosa strain TJ2014-049

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag I9X29_RS00660 Protein ID WP_003083773.1
Coordinates 142535..142816 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag I9X29_RS00665 Protein ID WP_003137009.1
Coordinates 142813..143040 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X29_RS00635 137786..139135 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
I9X29_RS00640 139184..139870 + 687 WP_003083762.1 FadR family transcriptional regulator -
I9X29_RS00645 139971..140705 + 735 WP_198341045.1 GntR family transcriptional regulator -
I9X29_RS00650 140909..141295 + 387 WP_003083767.1 aegerolysin family protein -
I9X29_RS00655 141327..142235 - 909 WP_198341046.1 LysR family transcriptional regulator -
I9X29_RS00660 142535..142816 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
I9X29_RS00665 142813..143040 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
I9X29_RS00670 143216..143836 - 621 WP_198341047.1 hypothetical protein -
I9X29_RS00675 143937..144437 + 501 WP_003101228.1 LEA type 2 family protein -
I9X29_RS00680 144510..144851 + 342 WP_003101229.1 alkylphosphonate utilization protein -
I9X29_RS00685 144933..146360 - 1428 WP_198341049.1 GABA permease -
I9X29_RS00690 146529..148022 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T183571 WP_003083773.1 NZ_CP065867:c142816-142535 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T183571 NZ_CP087114:c1243136-1242825 [Bartonella machadoae]
ATGGTAGCGATAATAAAAACAACAGATGAATTTGATGAATGGTTAGAAAAGCTTAAAGACAGAAAAGCTGCCGATATAAT
TCTTGCAAGACTTCATAAAATTCGTTCAGGGCTTTTAGGTGATGTTAAATTTTTTCATGGTATAGGTGAATTACGTATCC
ACTATGGCGCGGGTTACAGGATTTATTTCACTCAAAAAGGTAATAAAATCATTATATTGCTTTGTGGTGGTGACAAATCC
ACACAATCCAAAGATATTCAAAAAGCCTTATCTCTCTTGGAGGACCTTAAAAATGAAATTGAAAACCTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT183571 WP_003137009.1 NZ_CP065867:c143040-142813 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT183571 NZ_CP087114:c1242844-1242563 [Bartonella machadoae]
ATGAAATTGAAAACCTTTAACTTTGAAAAACACCTCACAACACCAGAATCTCAAGAAGTCTTTTTAAACGAAGCCTTCAA
AACTGGTGATGCTGCGCATATCGCAGATGCTCTTGGTATCGTTGCCCGCGCTCAAAATATGAGTGCATTAGCAAAGGAAA
CAAACCGTGAACGCAGTGGTTTATATCGCTCCCTTAGCAAAACGGGTGACCCTAGACTTTCTACTTTAGTTGCTGTGCTC
TCTGCCCTTAATTTGCAATTAAGCGTACAATCTACTCCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References