Detailed information of TA system TA183568

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3554925..3556146
• Replicon: chromosome
• Accession: NZ_CP065866
• Organism: Pseudomonas aeruginosa strain TJ2019-017

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: I9X27_RS16310
• Protein ID: WP_003102740.1
• Coordinates: 3555568..3556146 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I9X27_RS16305
• Protein ID: WP_003088112.1
• Coordinates: 3554925..3555479 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9X27_RS16280	3550493..3551044	+	552	WP_003102727.1	XRE family transcriptional regulator	-
I9X27_RS16285	3551041..3551439	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
I9X27_RS16290	3551452..3551775	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
I9X27_RS16295	3552106..3552567	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
I9X27_RS16300	3552572..3554767	+	2196	WP_014603034.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
I9X27_RS16305	3554925..3555479	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
I9X27_RS16310	3555568..3556146	+	579	WP_003102740.1	HD domain-containing protein	Toxin
I9X27_RS16315	3556255..3557442	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
I9X27_RS16320	3557432..3559603	-	2172	WP_014603035.1	type I secretion system permease/ATPase	-
I9X27_RS16325	3559593..3560870	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T183568 WP_003102740.1 NZ_CP065866:3555568-3556146 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T183568 NZ_CP087114:1150000-1150314 [Bartonella machadoae]
ATGATACATAAAAGAATGAATAAAGGTGATTTGGTGATTGAATCTTTTGCGGATAAGCGATGTAAAGATCTTTTAGAAGG
TAACCCGCCCAGAGGTTTTCCTACAACTCTAGTGCGTATCGCCCAAAGAAAATTGTTTATGCTCGATAAAGCAGTTGATC
TCAAAGATTTACGTAGTCCTCCGGGAAATCGCCTAGAATTATTGAAAGGAGAACGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGTATTTGTTTTGAATGGCGTTCCAATGGCGCCTATGAAGTTGAAATCGTAGATTATCATTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT183568 WP_003088112.1 NZ_CP065866:3554925-3555479 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT183568 NZ_CP087114:1150331-1150627 [Bartonella machadoae]
ATGAGAAATTATAGTGCTATACATCCCGGAGAAATTTTACGGGAGGAATATTTAAAAGAATATGCTCTTTCTGCTTATGC
CCTTGCAAAAGCTTTGAATGTTCCACGTACAAGGATAGAACGTATTATTGCTGAAAAAAGTCCAGTGACTCCTGATACAG
CACTAAGATTAGCCTATTTTTTTGATACAACAGCTGAATTTTGGCTTAACATGCAAGCTGCTTACGACGTTAGTATATTA
CAAACTGAAAAAGCAGATGAATTTTCCAAAATCAATAAATTTGAATGTAGAGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07