Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1590523..1592218 Replicon chromosome
Accession NZ_CP065866
Organism Pseudomonas aeruginosa strain TJ2019-017

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag I9X27_RS07405 Protein ID WP_003112901.1
Coordinates 1590523..1591392 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1C7C9F9
Locus tag I9X27_RS07410 Protein ID WP_017001846.1
Coordinates 1591385..1592218 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X27_RS07380 1586531..1587382 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
I9X27_RS07385 1587423..1588430 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
I9X27_RS07390 1588427..1589203 + 777 WP_003112898.1 ABC transporter permease -
I9X27_RS07395 1589209..1589970 + 762 WP_017001847.1 SDR family oxidoreductase -
I9X27_RS07400 1589984..1590514 + 531 WP_023119438.1 cupin domain-containing protein -
I9X27_RS07405 1590523..1591392 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
I9X27_RS07410 1591385..1592218 + 834 WP_017001846.1 IclR family transcriptional regulator Antitoxin
I9X27_RS07415 1592205..1593002 + 798 WP_017001845.1 SDR family oxidoreductase -
I9X27_RS07420 1592995..1594677 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
I9X27_RS07425 1594688..1595491 + 804 WP_003453564.1 aspartate dehydrogenase -
I9X27_RS07430 1595503..1596987 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T183566 WP_003112901.1 NZ_CP065866:1590523-1591392 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T183566 NZ_CP087114:c798538-798257 [Bartonella machadoae]
ATGAAATTGAAAACCTTTAACTTTGAAAAACACCTCACAACACCAGAATCTCAAGAAGTCTTTTTAAACGAAGCCTTCAA
AACTGGTGATGCTGCGCATATCGCAGATGCTCTTGGTATCGTTGCCCGCGCTCAAAATATGAGTGCATTAGCAAAGGAAA
CAAACCGTGAACGCAGTGGTTTATATCGCTCCCTTAGCAAAACGGGTGACCCTAGACTTTCTACTTTAGTTGCTGTGCTC
TCTGCCCTTAATTTGCAATTAAGCGTACAATCTACTCCATAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30867.22 Da        Isoelectric Point: 5.7725

>AT183566 WP_017001846.1 NZ_CP065866:1591385-1592218 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV

Download         Length: 834 bp

>AT183566 NZ_CP087114:c798830-798519 [Bartonella machadoae]
ATGGTAGCGATAATAAAAACAACAGATGAATTTGATGAATGGTTAGAAAAGCTTAAAGACAGAAAAGCTGCCGATATAAT
TCTTGCAAGACTTCATAAAATTCGTTCAGGGCTTTTAGGTGATGTTAAATTTTTTCATGGTATAGGTGAATTACGTATCC
ACTATGGCGCGGGTTACAGGATTTATTTCACTCAAAAAGGTAATAAAATCATTATATTGCTTTGTGGTGGTGACAAATCC
ACACAATCCAAAGATATTCAAAAAGCCTTATCTCTCTTGGAGGACCTTAAAAATGAAATTGAAAACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C9F9

References