Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5324479..5326071 Replicon chromosome
Accession NZ_CP065865
Organism Pseudomonas aeruginosa strain TJ2019-022

Toxin (Protein)


Gene name hipA Uniprot ID A0A550F7X0
Locus tag I9X26_RS25360 Protein ID WP_008569834.1
Coordinates 5324746..5326071 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID W6RJ44
Locus tag I9X26_RS25355 Protein ID WP_003459718.1
Coordinates 5324479..5324745 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X26_RS25330 5320650..5321486 + 837 WP_198340078.1 radical SAM protein -
I9X26_RS25335 5321488..5322051 + 564 WP_073653226.1 AAA family ATPase -
I9X26_RS25340 5322321..5322851 - 531 Protein_5012 inositol monophosphatase -
I9X26_RS25350 5324155..5324430 - 276 Protein_5014 inositol monophosphatase -
I9X26_RS25355 5324479..5324745 - 267 WP_003459718.1 helix-turn-helix domain-containing protein Antitoxin
I9X26_RS25360 5324746..5326071 - 1326 WP_008569834.1 HipA domain-containing protein Toxin
I9X26_RS25365 5326551..5329010 + 2460 WP_043156666.1 site-specific integrase -
I9X26_RS25370 5329317..5330624 + 1308 WP_058133198.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5308155..5345655 37500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49296.90 Da        Isoelectric Point: 5.0326

>T183561 WP_008569834.1 NZ_CP065865:c5326071-5324746 [Pseudomonas aeruginosa]
MHNLTLQVYRDGQWRNAMELRFEQPEEGLEGACAYGYQQGYLVDSLESVGTRLNAAVSAAYPLGWDSWRDKKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAIAGSPVLGFTRDEVISRDSRFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDADAVQHWFVKFARNKASQTDQDILRSEYCFYRAVQQLGMDTVAAEGLAL
EEGNKPSLWMHRFDREISSTGVCRTAVESMYSLCGVTEAGSYMLHTQVLGKLVELWRAVGQEQQVGDLVFEYMRRDLLNQ
ILGNSDNHGRNTAILRSEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGDVNWRAACDEVAEWIDADELFQRLRLA
AQDFLALPDLLSAQRLPDSTMSHPRIALRNLQQRMLQWGLV

Download         Length: 1326 bp

>T183561 NZ_CP087111:c3113500-3113213 [Pseudomonas palleroniana]
ATGACTGAATTTAAAGATTTCGACATAGCCGAATACCTCAAGACCCCCGAGGACATGGCCGAGTATCTTGAAGCCTCTTT
CGAGGAGGATTCAGGTGACGGATTGCTGATTCGTTCAGCCCTTAATCATATCGCTCGCGCCCAAGGCATGACCCAAATCG
CCCGCGACGCCGGCCTCGGACGCGAAAGCTTGTACAAAGCCCTTTCCAGCACTGGCAATCCCGAATTCGCGACTATCATG
AAGGTCATGAAAGCGCTGGGGCTGAAGCTCCACGCCAGCGCTCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9933.55 Da        Isoelectric Point: 10.9502

>AT183561 WP_003459718.1 NZ_CP065865:c5324745-5324479 [Pseudomonas aeruginosa]
MDILERNRILNELQQQLASGEITIGGAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNSVFNPFGMQV
GIVPKTPR

Download         Length: 267 bp

>AT183561 NZ_CP087111:c3113807-3113493 [Pseudomonas palleroniana]
ATGATCCGTTTCAAGAGATCCGCCGAGTTTCAGGAGTGGTTTCATTCGTTGCGCGATAAACCCGCCCGTGGACGAGTACT
GACAAGATTAGATAACGCAACGATGGGCAACTTCGGAGACTGCGAAACCGTTGGAAATGGCGTATCGGAAATGCGCATCC
ACTATGGCCCGGGATACCGGGTTTACTTCATGCGCATAGGTGAGGTGGTTTACCTGCTGTTGATAGGAGGCGATAAATCA
ACGCAACAGCGCGACATTCAGCGTGCGAAACAAATTGCAGATGAGTTTAGAAAAAAAGGAGTGGTCCATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A550F7X0

Antitoxin

Source ID Structure
AlphaFold DB W6RJ44

References